| 郭英俊 毛海婷 聂林 张稳 曲迅.ASICs的胞内分布及其功能调节机制的研究进展[J].,2014,14(16):3177-3180 |
| ASICs的胞内分布及其功能调节机制的研究进展 |
| The Researching Progress in Regulation Mechanismof IntracellularDistribution and Function of ASICs |
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| DOI： |
| 中文关键词: ASICs 胞内分布与转运 胰岛素 肿瘤 |
| 英文关键词: ASICs Intracellular distribution and transportation Insulin Tumor |
| 基金项目:国家自然基金面上项目（81072406） |
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| 中文摘要: |
| 随着对酸敏感离子通道（Acid-sensing ion channels, ASICs）研究的不断深入，其在临床相关疾病中的功能研究也逐渐受到重
视。ASICs 的功能异常与一系列临床疾病和症状密切相关，包括神经系统肿瘤、缺血性损伤、癫痫、疼痛以及亨廷顿氏症等。在细胞
内正常的分布与定位是AISCs 发挥其生理功能的前提，而多项研究已经确认，在正常生理的状态下，ASICs 在细胞内具有相对固
定的分布方式。换言之，正常的细胞内存在着可以对ASICs 的分布进行调节的调控系统。目前也发现了包括PICK1、HSP70 等与
之相关的一系列物质分子。鉴于ASICs 在人体诸多生理、病理过程中发挥重要作用，对ASICs 功能异常的相关研究便成为了目前
基础研究工作的重点之一。本文拟就ASICs 在细胞内的分布定位及其转运调节机制作一综述，进而初步探讨其在临床应用中的
前景。 |
| 英文摘要: |
| Along with the deeper understanding of the functions of Acid-sensing ion channels (ASICs), we got more and more
clinical researches related to them. The abnormality of ASICs is, to a great degree, responsible for numerous diseases, including
Neurologic tumors, ischemic injury, seizure, pain and Huntington's disease, and many reports have identified that there is a relative fixed
intracellular distributing pattern for ASICs under physiological status. In another word, there exists a intracellular regulatory system for
ASICs distribution. It is the basement for ASICs’functions that ASICs distribute normally. Up to now, we have found a series of relative
molecules, such as PICK1 and HSP70. Seeing the significance of ASICs in many physiological and pathological processes, it is a
researching point to identify the abnormities of ASICs’function. This review will simply conclude the intracellular distribution and
transportation mechanismof ASICs. Furthermore, the concomitant therapeutic implications will also be discussed. |
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