| 杨军 朱铁锤 刘向东 张连云 张瑞芳.血清胱抑素C和尿微量白蛋白在慢性肾小球肾炎早期肾功能
损害评估中的意义[J].,2014,14(16):3094-3096 |
| 血清胱抑素C和尿微量白蛋白在慢性肾小球肾炎早期肾功能
损害评估中的意义 |
| SerumCystatin C and Urinary Albumin in Patients with ChronicGlomerulonephritis Early Renal Damage Assessment of the Significance |
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| DOI： |
| 中文关键词: 血清胱抑素C 尿微量白蛋白 慢性肾小球肾炎 肾功能损害 |
| 英文关键词: Serumcystatin C Urinary albumin Chronic glomerulonephritis Renal dysfunction |
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| 中文摘要: |
| 目的：探讨血清胱抑素C和尿微量白蛋白在慢性肾小球肾炎早期肾功能损害评估中的意义。方法：选取2010 年9 月至2013
年7 月我院收治的86 名慢性肾小球肾炎患者，设为观察组。另选取同期在我院体检的年龄、性别等资料与之匹配的66 名健康者
设为对照组。分别对患者的CysC 以及mALB 的含量进行测定，并进行统计分析。结果：观察组和对照组的Cys C含量分别为
（2.68± 1.19）mg/L、（0.83± 1.04）mg/L，观察组明显高与对照组；mALB 的含量观察组为（38.16± 4.25）mg/L，相比于对照组的
（6.87± 3.93）mg/L明显升高；Cys C及mALB 阳性指标的检出率分别为75.58%、76.74%，而Cys C与mALB 进行联合检测，检出
率为91.86%，相比于单指标的检出率明显提高。差异具有统计学意义（P<0.05）。通过对慢性肾小球肾炎患者的两项指标进行相关
性分析，发现血清Cys C和尿mALB 的含量呈显著的正相关(r=0.941，P<0.05)。结论：将CysC与mALB 相结合检测用以对慢性肾
小球肾炎患者早期肾功能损害进行评估，检出率和敏感性均明显高于单指标检测。 |
| 英文摘要: |
| Objective: To investigate serum cystatin C and microalbuminuria in patients with chronic glomerulonephritis early
renal damage assessment of significance.Methods:from September 2010 to July 2013 in our hospital, 86 patients with chronic
glomerulonephritis, set the observation group. Select another examination in our hospital over the same period by age, sex and other data
matched 66 healthy subjects as controls. Respectively, as well as the patient's CysC mALB content were measured, and statistically
analysis.Results:The study group and the control group Cys C levels were (2.68± 1.19) mg/L, (0.83± 1.04) mg/L, the observation group
was significantly higher compared with the control group; mALB content of the observation group (38.16± 4.25) mg/L, compared to the
control group (6.87± 3.93) mg/L significantly increased; Cys C and mALB positive indicators detection rate was 75.58%, 76.74%, while
the Cys C and mALB joint detection, prosecution the rate was 91.86%, compared to the single index detection rate has improved
significantly. Difference was statistically significant (P<0.05). Through the two patients with chronic glomerulonephritis indicators
correlation analysis found that serum Cys C and urine mALB levels showed a significant positive correlation (r=0.941, P<0.05).Conclusion:The combination of CysC with mALB to detect chronic glomerulonephritis patients with early renal damage assessment, the
detection rate and sensitivity were significantly higher than the index detection. |
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