| 刘海霞 陈必良 李佳 陈嘉彦 梁声茹.EMT参与肿瘤侵袭转移的研究进展[J].,2014,14(14):2790-2793 |
| EMT参与肿瘤侵袭转移的研究进展 |
| The Research Progress of EMT in Tumor Invasion and Metastasis |
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| DOI： |
| 中文关键词: 上皮间质转化（EMT） 肿瘤 侵袭转移 |
| 英文关键词: Epithelial-mesenchymal transition(EMT) Tumor Invasion and Metastasis |
| 基金项目: |
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| 中文摘要: |
| 在癌症类型中，上皮癌占绝大多数。从良性腺瘤过渡到恶性癌和转移期间,上皮肿瘤细胞获得去分化、迁移和入侵行为,同时
上皮-间质转化(epithelial-mesenchymal transition EMT)伴随着显著的细胞形态学变化、细胞与细胞间及细胞与基质之间的粘附性
丢失及重塑、并获得迁徙和侵袭能力。正如完全分化的上皮细胞转换成低分化、迁移和侵入性间质细胞，其涉及到一个高度的细
胞可塑性、大量不同的基因和表观遗传学改变,因此EMT 本身是一个多阶段的过程。该综述的目的是系统地总结EMT分子机制
及EMT 与肿瘤关系的最新进展。 |
| 英文摘要: |
| Epithelial cancers make up the vast majority of cancer types, and during the transition from benign adenoma to
malignant carcinoma and metastasis, epithelial tumor cells acquire a de-differentiated, migratory and invasive behavior. This process of
epithelial-mesenchymal transition (EMT) goes along with dramatic changes in cellular morphology, the loss and remodeling of cell-cell
and cell-matrix adhesions, and the gain of migratory and invasive capabilities. As fully differentiated epithelial cells convert into poorly
differentiated, migratory and invasive mesenchymal cells, EMT itself is a multistage process, involving a high degree of cellular plasticity
and a large number of distinct genetic and epigenetic alterations. The aimof this review is to summarize the newest advances of EMT and
tumors. |
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