| 叶海燕 周径 张彦忠 李秀芳 陈大双 李培.磷酸西格列汀治疗2 型糖尿病疗效观察[J].,2014,14(14):2745-2746 |
| 磷酸西格列汀治疗2 型糖尿病疗效观察 |
| The Clinical Observation of Sitagliptin Phosphate Tabletsin the Treatment of type 2 Diabetes |
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| DOI： |
| 中文关键词: 2 型糖尿病 磷酸西格列汀 疗效 安全性 |
| 英文关键词: Type 2 diabetes Sitagliptin phosphate tablets Efficacy Safety |
| 基金项目:2011 年全国名中医传承工作室建设项目(国中医药人教发（2011）41 号) |
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| 中文摘要: |
| 目的：观察口服降糖药磷酸西格列汀对2 型糖尿病患者的临床疗效及安全性。方法：对47 例血糖控制欠佳的2 型糖尿病患
者进行为期12 月的磷酸西格列汀治疗并观察，分别在治疗前和治疗3、6、12 个月后检测空腹血糖( FBG) 、餐后2 h血糖、胰高血
糖素、糖化血红蛋白、血常规、血压、肝肾功能、体重。结果：磷酸西格列汀治疗3、6、12 个月后空腹血糖及餐后2 h血糖、胰高血糖
素、糖化血红蛋白水平均较治疗前明显下降(P＜0.05 或0.01)，体重、血压、肝肾功能、血常规无明显变化(均P＞0.05)。结论：磷酸
西列汀可显著降低2 型糖尿病患者的空腹血糖、餐后2 h血糖、糖化血红蛋白及抑制α细胞活性，同时无明显副作用，是治疗2 型
糖尿病有效且安全的口服降糖药。 |
| 英文摘要: |
| Objective:To observe the clinical effect and safety of Sitagliptin phosphate tablets in treating patients for type 2
diabetes.Methods:47 patients with poor glycaemic control in type 2 diabetes were treated with Sitagliptin phosphate tablets for 12
months. During the observation, FBG, PBG, HbA1C, glucagon, blood routine, blood pressure, liver and kidney function and body weigh
were detected at the time of 3, 6, 12 months.Results:After treated with Sitagliptin phosphate tablets for 3, 6, 12 months, FBG, PBG,
glucagon and HbA1C were markedly decreased (P<0.05 or 0.01). But the weight, blood pressure, liver and kidney function and blood
routine had no significant change (P>0.05).Conclusion:Sitagliptin phosphate tablets can lower the lever of FBG, PBG and HBA1C, and
inhibit the activity of αcell. Sitagliptin phosphate tablets have no obvious side effect. It is the safe and effective oral hypoglycemic agents
in treatment of type 2 diabetes. |
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