| 陈莹莹 孙光玲 兰倩 潘丽丽 吕会娟 苏志强.Toll样受体与脑缺血[J].,2014,14(12):2369-2371 |
| Toll样受体与脑缺血 |
| Toll sample receptor and cerebral ischemia |
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| DOI： |
| 中文关键词: 脑缺血 TLR 脑缺血耐受 |
| 英文关键词: Cerebral ischemia TLR Cerebral ischemia tolerance |
| 基金项目:国家自然科学基金重点项目（81070945） |
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| 摘要点击次数: 901 |
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| 中文摘要: |
| 脑缺血是临床上的常见病，目前已成为导致人类死亡的主要原因之一，脑缺血后存在一个十分复杂的病理生理过程，涉及
很多机制。包括离子稳态的破坏，自由基的损伤作用，兴奋性氨基酸的毒性作用，免疫炎症作用和细凋亡等机制。TOLL样受体即
TLR（Toll-like receptor TLR）,是一类介导天然免疫的跨膜信号传递受体家族，在细胞活化信号传导中发挥着重要作用，已成为联
系天然免疫和后天性免疫的桥梁。现在共发现了13 中TOLL样体，最近发现Toll 样受体能诱发机体的固有免疫应答，介导炎症
因子细胞因子的释放，与全身多种重要器官的缺血再灌注损伤有关，研究表明部分TOLL 样受体在脑缺血损伤中发挥十分重要
的作用。本文就TLR 的结构、分布、配体、信号转导通路及其脑缺血中的作用综述如下。 |
| 英文摘要: |
| Cerebral ischemia is a clinical common disease, has become the cause humanity to one of the leading causes of death,
after cerebral ischemia there is a very complex pathophysiological process, involving many mechanism. Including ion steady destruction,
free radical damage effect, excitatory amino acid toxic effect, the immune inflammation function and fine apoptosis mechanism, etc.
TOLL sample receptor namely TLR (at like receptor TLR), is a kind of natural immune mediated the transmembrane signal transfer
receptor family, in cell activation signal conduction plays an important role, has become a contact natural immunity and acquired immune
bridge. Now were found in 13 TOLL sample body, recently discovered TOLL samples under physical induced the body's natural immune
response, mediated inflammatory factor cytokines release, and the whole body many important organ ischemia-reperfusion injury related,
study indicates that partial TOLL sample receptor in the brain ischemia injury plays a very important role. This paper TLR structure,
distribution, ligand, signal transduction pathway and the role of cerebral ischemia were reviewed as follows. |
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