| 谢朗 黄宗海 陈飞俞 金龙 崔春晖 黎志超.不同压力智能型人工肛门封堵装置封堵效果试验[J].,2014,14(12):2234-2238 |
| 不同压力智能型人工肛门封堵装置封堵效果试验 |
| Blocking Effect Test of Different Pressures of IntelligentColostomy Closure Device |
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| DOI： |
| 中文关键词: 智能型人工肛门封堵装置 动物试验 结肠造口模型 肠管局部血流灌注量 两因素重复测量分析 两因素裂区分析 |
| 英文关键词: Intelligent colostomy closure device Animal testing Colostomy model Partial intestinal perfusion Two-factor repeated
measure analysis Two-factor split-plot analysis |
| 基金项目:广州市海珠区科技计划项目（2010-C-17） |
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| 中文摘要: |
| 目的：比较不同压力智能型人工肛门封堵装置的效果。方法：选用8-10 月龄西藏小型猪进行动物试验。先进行结肠造口动物
模型制备，再设计为3 个不同气囊压力组分别接受试验。观察动物一般情况、造口泄露率、造口处肠壁粘膜组织中性粒细胞和淋
巴细胞及肠管局部血流灌注量，并对应进行各影响因素的综合分析。结果：33.33 mmHg 的压力组较之于其它两组，一般情况较
差，体重下降明显（p=0.004）；造口泄漏率最低，但造口处肠壁粘膜组织中性粒细胞和淋巴细胞显著上升（p=0.000）；肠管局部血流
灌注量显著下降（p=0.000），提示压力太大易致使造口处血运变差及并发感染。结论：压力过大时对周围组织及肠管压迫严重，容
易引起缺血、坏死、感染等并发症。压力过小时又易发生泄漏，无法达到封堵目的。以气囊压力约18 mmHg较为适宜。 |
| 英文摘要: |
| Objective:To observe the effects of different pressure of intelligent colostomy closure device.Methods:To do animal
experiments with 8-10 months old Tibet mini-pigs. First prepare with animal models with colostomy, and design of three different groups
with balloon pressure to test, to observate the animals' general, stoma leakage rate, stoma neutrophils and lymphocytes and intestinal perfusion
partial bowel mucosa and correspond to conduct a comprehensive analysis of each factor.Results:The general condition of the
33.33 mmHg pressure group were more poor than other two groups, their body weight decreased significantly (p=0.004); Ostomy leakage
rate was lowest, but stoma neutrophils and lymphocytes in intestinal mucosa increased significantly (p=0.000); Partial intestinal perfusion
decreased significantly (p=0.000), too much pressure will cause to poor blood supplement in stoma and susceptible.Conclusion:If
pressure is excessive, it will oppress on the surrounding tissue and intestinal severely, to cause ischemia, necrosis, infection and other
complications. If pressure is too small, it will prone to leak, and it can not achieve the purpose of blocking. So the balloon pressure in
18mmHg is more appropriate. |
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