| 董开芯 王正强 于新娟 王莉莉 董全江.胃肠道菌群与肿瘤发生的关系[J].,2014,14(11):2196-2200 |
| 胃肠道菌群与肿瘤发生的关系 |
| The Association Between Gastrointestinal Microbiota andthe Development of Cancer |
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| DOI： |
| 中文关键词: 胃肠道菌群 肿瘤 致病机制 |
| 英文关键词: Gastrointestinal microbiota Tumor Pathogenesis |
| 基金项目: |
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| 摘要点击次数: 753 |
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| 中文摘要: |
| 人体的胃肠道菌群构成一个庞大、复杂的微生态系统，并且随着年龄的增长而发生动态变化，成年后菌群的结构达到动态
平衡。胃肠道菌群具有参与物质代谢、促进机体免疫系统的发育和抑制病原菌定植等生理作用。菌群失调会导致各种疾病的发
生，如肠易激综合征、炎症性肠病、肥胖症、１ 型糖尿病、肠道恶性肿瘤等。本文就胃肠道菌群与肿瘤发生发展关系的最新研究作
一综述，并根据最新提出的Alpha-Bug 学说和driver-passenger 学说，论述了肠道菌群促进大肠癌发生的机制。为阐明胃肠道肿瘤
的发生机制提供新的思路。 |
| 英文摘要: |
| The human gastrointestinal microbiota constitutes a huge and complex ecosystem. It changes with the age, achieving
the homeostasis until adulthood. Gut microbiota participates in the metabolism, promotes the development of the immune system and inhibits
the colonization of pathogens. Alterations of microbiota may result in various diseases, such as irritable bowel syndrome, inflammatory
bowel disease, obesity, type 1 diabetes, and intestinal malignant tumor. This paper reviews the association between gastrointestinal
microbiota and the development of cancer, and discusses mechanisms by which the gut microbiota promotes the development of colorectal
cancer according to the latest proposed Alpha-Bug and driver-passenger models. This would benefit for the understanding of
pathogenesis of gastrointestinal tumor. |
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