| 熊章鄂1 张攀2 赵博2 仝巧云1 王婷2△.Nrf2-ARE 信号通路在神经退行性疾病中的作用研究进展*[J].,2014,14(10):1991-1993 |
| Nrf2-ARE 信号通路在神经退行性疾病中的作用研究进展* |
| The Role of Nrf2-ARE Signal Pathway in Neurodegenerative Disease* |
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| DOI： |
| 中文关键词: Nrf2-ARE 信号通路 氧化应激 神经退行性疾病 |
| 英文关键词: Nrf2-ARE pathway oxidative stress neurodegenerative diseases |
| 基金项目:国家自然科学基金项目（81100957) |
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| 摘要点击次数: 910 |
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| 中文摘要: |
| 摘要：神经退行性疾病(Neurodegenerative disease) 是一类以神经元退行性病变为基础的慢性、进行性、不可逆的神经系统疾病的
总称，主要包括阿尔茨海默病(Alzheimer's disease，AD)、帕金森病(Parkinson's disease，PD)、亨廷顿舞蹈病(Huntington disease，HD)、
肌萎缩侧索硬化症(amyotrophic lateral sclerosis，ALS)、脊髓肌萎缩症(spinal muscular atrophy，SMA)、不同类型脊髓小脑共济失调
(spinal cerebella ataxias，SCA)等。其病因和发病机制十分复杂，其中，氧化应激学说近年来受到了人们的广泛关注和普遍认可。而
研究表明，Nrf2-ARE 信号通路是体内抗氧化应答机制中最重要的通路之一，其能对氧化应激导致的神经细胞损伤产生保护作
用，即阻止神经细胞的病变和凋亡，进而延缓神经退行性疾病的发生发展，因而有望成为神经退行性疾病的有效治疗靶标。本文
就Nrf2-ARE 信号通路结构特点及Nrf2-ARE 信号通路在神经退行性疾病中的作用研究进展作一综述。 |
| 英文摘要: |
| ABSTRACT:The neurodegenerative disease is a classof chronic progressive irreversible degenerative diseasesinthe nervous system. It
mainly contains Alzheimer's disease (AD), Parkinson disease (PD), Huntington disease (HD), amyotrophic lateral sclerosis (ALS), Spinal
meouscular atrophy (SMA), different types of spinal cerebella ataxia (SCA). Its etiologies and pathogeneses are very complex, among
which the theory of oxidative stress received widespread concern and general acceptance in recent years. Meanwhile, study shows that
Nrf2-ARE pathway is one of the most important antioxidant response pathway, which may protect the nerve cells from oxidative stress,
thereby delays the occurrence and development of degenerative diseases, thus to be an effective therapeutic target in neurodegenerative
diseases. In this review, we discuss the role of Nrf2-ARE pathway in neurodegenerative disease, together with the progress of the study
concerning it. |
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