| 高媛媛1 郭瑞友2△ 王莉2 毛德军2 李彬2.脑卒中后抑郁患者视黄醇结合蛋白4 和结合珠蛋白
的研究*[J].,2014,14(10):1938-1941 |
| 脑卒中后抑郁患者视黄醇结合蛋白4 和结合珠蛋白
的研究* |
| Study on the SerumRBP4 and Hp in the Patientswith Post-stroke Depression* |
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| DOI： |
| 中文关键词: 抑郁 缺血性脑卒中 结合珠蛋白 视黄醇结合蛋白4 |
| 英文关键词: Depression Ischemic stroke Hp RBP4 |
| 基金项目:青岛市科技局立项课题（06-2-2-4-nsh） |
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| 中文摘要: |
| 摘要目的：通过观察脑卒中后抑郁（post-stroke depression，PSD）患者血清结合珠蛋白（Hp）和视黄醇结合蛋白4(RBP4)的水平变
化，进一步明确PSD 可能的作用机理。方法：以缺血性脑卒中患者为研究对象，采用汉密尔顿抑郁量表（HAMD）筛选符合条件的
卒中后抑郁患者35 例，选择不伴抑郁的卒中病人35 例为对照组。于住院第3 周，应用酶联免疫吸附法检测病人血清Hp 和RBP4
的水平。结果：卒中后抑郁组血清Hp 和RBP4 浓度[分别为(130.89± 15.86) mg/L、(36.45± 5.02) mg/L]较对照组[分别为（92.42±
15.74）mg/L、（28.57± 5.08）mg/L]明显增高，差异有显著性意义（P＜0.05）。脑卒中后重度抑郁组血清Hp 和RBP4 的水平[分别为
（146.83± 10.08)mg/L、（40.83± 4.28）mg/L]显著高于轻度抑郁组[分别为（113.67± 9.18)mg/L、（31.76± 4.11）mg/L]及中度抑郁组[分
别为（130.73± 5.11)mg/L、（36.37± 1.17）mg/L]，中度抑郁组亦高于轻度抑郁组（P＜0.05）。血清Hp 和RBP4 水平与HAMD 评分的
Pearson 相关分析表明两者显著相关（相关系数分别为：r=0.913、P＜0.01；r=0.800、P＜0.01）。结论：PSD组中血清Hp 和RBP4 水平
相对于对照组有明显增高，并且该组中Hp 和RBP4 的水平变化与抑郁程度显著正相关，提示血清Hp 和RBP4 可能在脑卒中后
抑郁的发病机理中起着重要作用，并在一定程度上可反映脑卒中后抑郁的严重程度，并指导临床诊疗。 |
| 英文摘要: |
| ABSTRACT Objective：Through explore the change of the serumlevels of Hp and RBP4 in patients with post-stroke depression(PSD)
can further clarify the possible biological mechanism.Methods：By using Hamilton Rating Scale for Depression(HAMD), 35 patients
with post-stroke depression were recruited, and 35 patients without depression were divided into the control group. Two weeks after the
onset of stroke, serum levels of Hp and RBP4 were measured by enzyme-linked immunosorbent assay(ELISA). Results：The levels of Hp
and RBP4 in patientswith PSDwere significantly higher than that of the control group (130.89± 15.86mg/Lvs 92.42± 15.74mg/L, P=0.000;
36.45± 5.02 mg/L vs 28.57± 5.08 mg/L, p=0.000 respectively). Pearson correlation analysis showed the serum levels of Hp and RBP4
were positively correlated with the HAMD score（r=0.913, P＜0.01; r=0.800, P＜0.01 respectively）. The serumlevels of Hp and RBP4 in
patients with serious depression were higher than that in moderate and mild depression groups (146.83± 10.08 mg/L vs 130.73± 5.11
mg/L vs 113.67± 9.18 mg/L, 40.83± 4.28 mg/L vs 36.37± 1.17 mg/L vs 31.76± 4.11 mg/L), and that in moderate depression group were
higher than that in mild depression group (all P＜0.01).Conclusion: The serumlevels of Hp and RBP4 in depression group was increased
obviously than the control group, and it was positive correlation with the degree of depression significantly. The serum cytokines Hp and
RBP4 maybe play an important role in pathogenesis of post-stroke depression, and may be the markers of post-strok depression, all of
that can guide the diagnosis and the treatment in clinical. |
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