| 李白雪 张技 吴疆 冯全生 张传涛.体外肝细胞损伤模型分子机制探讨[J].,2014,14(9):1786-1789 |
| 体外肝细胞损伤模型分子机制探讨 |
| The Molecular Mechanismof Hepatic Cell InjuryModel in Vitro |
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| DOI： |
| 中文关键词: 肝损伤 细胞模型 体外 机制 |
| 英文关键词: Liver injury Cell model In vitro Mechanism |
| 基金项目:国家科技重大专项资助项目—基于转化医学的艾滋病、病毒性肝炎和结核病中医证侯生物学研究
（2012ZX10005001）；国家自然科学基金资助项（81102720） |
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| 中文摘要: |
| 肝损伤是临床常见的危害人类健康的疾病，是各种原因引起肝脏疾病的共同的表现，也是各型肝病共同的病理基础。建立
稳定可靠体外肝细胞损伤模型，对于肝损伤病理机制研究及有效防治肝损伤药物筛选提供了前提。针对肝细胞损伤分子机制不
同，目前已成功建立基于免疫损伤、氧化损伤、脂肪损伤等体外肝细胞损伤模型，用于临床药物筛选及疗效作用机制研究，本文对
目前常见体外肝细胞损伤模型及其发生的分子生物学机制进行探讨。 |
| 英文摘要: |
| Liver injury is a common clinical disease threatening people's health, it is a variety of liver diseases common performance
and pathological basis. Establishing the stable model of hepatic cell injury provides the precondition for studying on the
mechanism of liver injury and screening the drugs for prevention and treatment of liver injury. At present, hepatic cell injury models
based on different molecular mechanisms such as immune injury, oxidative damage, fatty liver injury, have been successfully
established, which applied for drugs screening and the mechanism of action of the drugs. This paper reviewed the common hepatic cell
injury model at present and its molecular mechanisms. |
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