| 崔海敏 王薇 王云鹏 赵斌 赖江华.大鼠酒精躯体依赖及动机行为研究[J].,2014,14(9):1622-1626 |
| 大鼠酒精躯体依赖及动机行为研究 |
| To investigate the Physical Dependence on Alcoholand Motivation Behavior of Rat |
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| DOI： |
| 中文关键词: 酒精依赖 自主活动 强迫游泳实验 戒断综合征 |
| 英文关键词: Alcohol dependence Locomotor activity Forced swimming test Withdrawal symptoms |
| 基金项目:国家自然科学基金项目（NSFC81172910） |
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| 中文摘要: |
| 目的：诱导大鼠产生酒精依赖，观察大鼠产生的躯体依赖及行为学改变。方法：20只雄性SD 大鼠，其中饮酒组和对照组各
10 只。通过6%(v/v)酒精溶液作为饮酒组大鼠唯一饮水来源共28d，测量血酒精浓度。根据旷场行为、戒断症状和强迫游泳等方法
来判断是否成功诱导大鼠产生酒精躯体依赖及动机行为改变。结果：整个实验过程饮酒组大鼠血酒精浓度没有发生明显变化。饮
酒组大鼠旷场测试中水平活动量在饮酒第7d 比对照组显著降低(P<0.05)；垂直活动量在饮酒第7、14d比对照组显著降低(P<0.05)；
饮酒组大鼠戒断2~48h酒精戒断评分均显著高于对照组(P<0.01)且评分在戒断第6h 最高；戒断24、48h 的大鼠在强迫游泳中绝
对不动时间比对照组显著延长(P<0.05)。结论：大鼠持续饮用6%(v/v)浓度酒精溶液可以诱导出大鼠对酒精的严重躯体依赖和抑
郁状态，并抑制大鼠在新奇环境中的活动能力和动机行为。 |
| 英文摘要: |
| Objective:To investigate the physical dependence on alcohol and motivation behavior of rat.Methods:20 male SD
rats were divided into an alcohol group and control group, with 10 rats in each group. 6% (v/v) alcohol solution was provided as the sole
drinking source for 28 consecutive days. Blood ethanol levels were detected. According to open-field behavior, withdrawal symptoms
and forced swimming, the induction of the physical dependence to alcohol in rats and motivation behavior changes were determined.Results:Blood ethanol levels (BELs) of alcohol group had no significant changes in the whole experiment. The horizontal activity in rats
of alcohol group reduced significantly at 7d (P<0.05) compared with that in the control group. The vertical activity in alcohol group
reduced significantly at 7d and 14d (P<0.05). The EWS score in alcohol treated rats were significantly higher than that in the control
group after 2 ~ 48h of alcohol withdrawal (P<0.01), and the EWS score reached the peak after 6h of withdrawal. The forced swimming
test showed increased anxiety in alcohol treated rats during the 24, 48h withdrawal period (P<0.05).Conclusion:The continuous drinking
of 6%(v/v) alcohol solution for 28d is sufficient to induce severe physical dependence and depression, and inhibit the locomotion and
motivation behaviors in a novel environment. |
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