| 李娜孙朝阳周波郭恩松卢豪陈刚翁丹卉Δ.Cdk1 在浆液性卵巢癌中的表达及其与化疗耐药及预后的相关性*[J].,2014,14(8):1467-1470 |
| Cdk1 在浆液性卵巢癌中的表达及其与化疗耐药及预后的相关性* |
| Expression of Cdk1 Protein in Serous Ovarian Cancer Correlates toChemo-Resistance and Prognosis of Patients* |
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| DOI： |
| 中文关键词: Cdk1 免疫组化 卵巢癌 化疗耐药 |
| 英文关键词: Cdk1 IHC Serous ovarian cancer Chemo-resistance |
| 基金项目:国家自然科学基金青年基金项目(81000979/H1609)；国家自然科学基金项目(81272859)； |
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| 中文摘要: |
| 摘要目的：卵巢癌是女性生殖致死率最高的恶性肿瘤。Cdk1 作为细胞周期依赖性激酶中的核心分子，对肿瘤细胞的发生发展具
有重要作用。本文旨在探讨Cdk1 蛋白在上皮性浆液性卵巢癌中的表达情况，并分析其表达水平与患者临床病理特征、化疗反应
及预后之间的关系。方法：采用免疫组化法检测68 例浆液性卵巢癌中Cdk1 蛋白的表达情况，并结合临床资料分析Cdk1蛋白的
表达水平在浆液性卵巢癌患者中的意义。结果：Cdk1 在浆液性卵巢癌患者中具有不同程度的阳性表达，其表达水平和患者的年
龄、病理分化程度、淋巴结转移情况及临床分期无明显相关性(P＞0.05)，但是其高表达与化疗耐药明显相关(P = 0.040)。化疗耐
药的卵巢癌患者中Cdk1 的蛋白表达明显高于化疗敏感组，并且生存分析发现，高表达Cdk1 的患者预后较差。结论：本研究证明
Cdk1 在浆液性卵巢癌中有较高表达,并且Cdk1 的表达与卵巢癌化疗后复发有关，高的Cdk1表达预示着较差的预后。Cdk1 可能
是晚期浆液性卵巢癌治疗的新靶点。 |
| 英文摘要: |
| ABSTRACT Objective:To study the Cdk1 protein expression of ovarian cancer tissues and the relationship between Cdk1 level
and the chemotherapy resistance and prognosis of ovarian cancer patients. Methods:The Cdk1 protein expression was assessed by
immunehistochemistry (IHC) in 68 specimens of serous ovarian cancer. A correlation was analyzed between Cdk1 protein expression and
clinical pathological features. The Kaplan-meier curve was used to analyse the correlation of Cdk1 expression with prognosis of ovarian
cancer patients. Results:Cdk1 protein expression level was not related to age, lymph nodes metastasis, clinical stage and pathological
differentiation(P＞0.05), while high Cdk1 expression was associated with chemotherapy resistance(P = 0.040). And the chemo-resistance
patients group had a much higher Cdk1 expression. Survival analysis found out that Cdk1 expression was an independent factor of PFS of
ovarian cancer patients. Conclusion:Our data represent firstly that Cdk1 protein expression may contribute to chemotherapy resistance
and prognosis of serous ovarian carcinoma. Cdk1 may be a promising therapy target for serous ovarian cancer. |
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