| 于翔1 陆佳嘉2 王秦2 于晓妉3 杨永青1△.巨噬细胞凋亡对结核分枝杆菌感染的机制研究进展[J].,2014,14(5):972-974 |
| 巨噬细胞凋亡对结核分枝杆菌感染的机制研究进展 |
| Progress of Research on the Mechanismof Apoptosis of MacrophagesInfected with MycobacteriumTuberculosis |
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| DOI： |
| 中文关键词: 巨噬细胞 凋亡 结核分歧杆菌 感染 机制 进展 |
| 英文关键词: Macrophage apoptosis Mycobacteriumtuberculosis infection mechanism progress |
| 基金项目:国家自然科学基金项目(J1103520) |
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| 中文摘要: |
| 摘要：结核病是一种严重危害人类健康的慢性传染性疾病，主要由结核分枝杆菌感染导致，结核分枝杆菌进入人体后，与免疫防
御的第一道屏障—巨噬细胞发生反应，部分菌株在细胞内长期生存、繁殖，是导致结核病转归的决定性因素。感染早期，结核分枝
杆菌的繁殖受到巨噬细胞凋亡的抑制，随着高效价、高毒力菌株繁殖速度的增加，抗巨噬细胞凋亡作用不断增强，使自身繁殖得
到有效保护，为菌株的生长提供了充足、适宜的胞内环境。因此，调控结核分枝杆菌对巨噬细胞凋亡进程的抑制作用，是预防和治
疗结核病的关键。 |
| 英文摘要: |
| ABSTRACT:Tuberculosis is a chronic infectious disease serious harm to human health, is mainly composed of Mycobacterium
tuberculosis infection. When Mycobacterium tuberculosis entered into the human body and led immune macrophage reaction, some
strains were long-termsurvival and made reproduction, which is the decisive factor leading to tuberculosis. In the early stage of infection,
Mycobacterium tuberculosis growth was inhibited by apoptosis of macrophages. With the increase of high titer, high virulent strains
breeding rate, the effect of macrophage on apoptosis increases ceaselessly, and make their own reproduction can be effectively protected,
providing sufficient, appropriate intracellular environment for the growth of strains. Therefore, the inhibition of Mycobacterium
tuberculosis to the regulation of macrophage apoptosis process is the key to the prevention and treatment of tuberculosis. |
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