| 黄澄刘裕英吕艳陈永烨李胜玲.参麦注射液联合无创正压通气治疗慢性阻塞性肺疾病
合并呼吸衰竭的临床观察[J].,2014,14(5):921-923 |
| 参麦注射液联合无创正压通气治疗慢性阻塞性肺疾病
合并呼吸衰竭的临床观察 |
| Clinical Observation on the Efficacy of Shenmai injection combined withNon-invasive Positive Pressure Ventilation in the treatment of Patients withChronic Obstructive Pulmonary Cisease Plus Respiratory Failure |
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| DOI： |
| 中文关键词: 参麦注射液 慢性阻塞性肺疾病 呼吸衰竭 脑钠肽 纤维蛋白原 D-二聚体 |
| 英文关键词: Shenmai injection Chronic obstructive pulmonary disease Respiratory failure Brain natriuretic peptide Fibrinogen D-dimer
作者简介：黄澄(1971-),女,本科,主治医师,主要从事急诊内科的
临床研究
（收稿日期：2013-06-30 接受日期：2013-07-24）
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| 中文摘要: |
| 摘要目的：观察参麦注射液联合无创正压通气治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的疗效及其对患者血清脑钠肽(BNP)、
纤维蛋白原和D- 二聚体水平的影响。方法：选取2010 年1 月至2012 年1 月我院收治的COPD 合并急性呼吸衰竭患者120 例，
随机分为观察组和对照组，每组各60 例，对照组予以常规治疗，观察组在对照组的基础上予以无创正压通气和参麦注射液治疗，
观察和比较两组治疗前后的pH 值、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)，、氧合指数(PaO2/FiO2)、纤维蛋白原、D-二
聚体和BNP 水平的变化。结果：治疗后，两组的pH、PaO2和PaO2/FiO2均较治疗前明显升高(P<0.01)，且观察组PaO2/FiO2水平较
对照组升高更为明显(P<0.05)；两组PaCO2、纤维蛋白原、D- 二聚体和BNP水平均较治疗前明显降低(P<0.01)，且观察组以上指标
水平明显低于对照组(P<0.01)。结论：参麦注射液联合无创正压通气治疗COPD合并呼吸衰竭的疗效显著，并可显著降低患者血
浆BNP、纤维蛋白原和D-二聚体水平。 |
| 英文摘要: |
| ABSTRACT Objective:To observe the efficacy of Shenmai injection combined with non-invasive positive pressure ventilation in
the treatment of patients with chronic obstructive pulmonary disease (COPD) plus respiratory failure and its effect on the serum levels of
brain natriuretic peptide (BNP), fibrinogen and D-dimer. Methods:120 patients with COPD plus acute respiratory failure, admitted from
January 2010 to January 2012, were randomly divided into the observation group and control group, 60 cases in each group. The control
group was given the conventional treatment, the observation group was treated with Shen Mai injection combined with noninvasive
positive pressure ventilation on the basis of control group, the levels of pH, arterial oxygen pressure (PaO2), arterial partial pressure of
carbon dioxide (PaCO2), oxygenation index (PaO2/FiO2), fibrinogen, D dimer and BNP were observed and compared before and after
treatment. Results:After treatment, the levels of pH, PaO2 and PaO2/FiO2 were significantly higher in two groups than those before
treatment (P<0.01), while the levels of PaO2/FiO2 increased more significantly compared with the control group (P<0.05). The levels of
PaCO2, fibrinogen, D-dimer and BNP were significantly lower than those before treatment (P<0.01), while the reduced levels were more
obvious in the observation group (P<0.01). Conclusiong:Shenmai injection combined with non-invasive positive pressure ventilation was
more effective to the COPD patients with respiratory failure, which obvioulsy increased the serumBNP, fibrinogen and D-dimer levels. |
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