| 卿克勤章帆吴李萍范丹周茜.血清同型半胱氨酸及尿酸水平检测对冠心病的临床价值研究[J].,2014,14(5):911-914 |
| 血清同型半胱氨酸及尿酸水平检测对冠心病的临床价值研究 |
| Study on the Clinical Value of SerumHomocysteine and UricAcid levels in the Coronary Heart Disease |
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| DOI： |
| 中文关键词: 同型半胱氨酸 尿酸 冠心病 急性心肌梗死 |
| 英文关键词: Homocysteine Uric acid Coronary heart disease Acute myocardial infarction |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：探讨血清同型半胱氨酸(Hcy)和尿酸(UA)水平检测对冠心病的临床价值。方法：选择经冠状动脉造影确诊为冠心病的
182例患者，分为以下3 组，稳定型心绞痛(SAP)组78 例，不稳定型心绞痛(UAP)组56 例，急性心肌梗死(AMI)组48 例。另外，随机
选择单纯性高血压患者60 例作为对照组，比较各组血清Hcy和UA水平并分析二者与各临床类型冠心病之间的关系。结果：⑴
冠心病组的血清Hcy和UA 水平明显高于单纯性高血压组(P<0.05)；⑵AMI组的血清Hcy和UA水平均明显高于UAP组和SAP
组(P<0.05)；⑶Spearman 相关分析显示：在AMl 组中血清Hcy 和UA 水平呈高度正相关(P<0.01)；⑷Logistic 风险回归显示：血清
Hcy和血清UA 升高是冠心病的危险因素(P<0.05)，而血清Hcy 升高是急性心肌梗死的独立危险因素(P<0.05)。结论：高Hcy与高
UA血症是冠心病发病的重要危险因素，联合监测二者对预防冠心病尤其是急性心肌梗死具有重要的临床意义。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of serum homocysteine and uric acid levels in the coronary heart disease
(CHD). Methods：182 patients with CHD diagnosed by coronary angioplasty were enrolled, including 78 SAP patients,m56 UAP patients
and 48 AMI patients, while 60 patients with simple essential hypertension (EH) were selected as controls. The levels of serum Hcy and
UA in all patients were determined, then their correlation with different groups were analyzed.Results： (1)The serumHcy and UA concentrations
in CHD group were both higher than those in EH group (P<0.05). (2)Serum Hcy and UA concentration in AMI group were
higher than those in SAP and UAP groups (P<0.05). (3)Spearman correlation analysis indicated serum Hcy and UA werer highly positive
correlated in AMI group(P<0.01). (4)Logistic regression analysis indicated the increase of serum Hcy and UA levels were the risk factors
in CHD, while the increase of serumHcy was single risk factor in AMI patients.Conclusion: Hyperhomocysteinemia and Hyperuricemia
were important risk factors in CHD, the detection of both serumHcy and UA were of great importance in the prevention of CHD. |
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