| 黄硕陈健贾谊君王永坤陆云姝吴克瑾△.三阴性乳腺癌中MMP9 和P53 的表达与其预后
的关系研究*[J].,2014,14(5):881-884 |
| 三阴性乳腺癌中MMP9 和P53 的表达与其预后
的关系研究* |
| Research on the Correlation of MMP9 and P53 Expressionwith the Prognosis of Triple Negative Breast Cancer* |
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| DOI： |
| 中文关键词: 基质金属蛋白酶9 P53 三阴性乳腺癌 预后 |
| 英文关键词: MMP9 P53 Triple negative breast cancer Prognosis |
| 基金项目:国家自然科学基金青年科学基金项目（81102016） |
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| 中文摘要: |
| 摘要目的：研究三阴性乳腺癌(triple negative breast cancer，TNBC)中基质金属蛋白酶9(matrix metal proteinase 9，MMP9)和P53 的
表达及其与三阴性乳腺癌预后的关系。方法：收集2002 年3 月至2011 年7 月上海交通大学医学院附属新华医院普外科诊治且
临床资料完整的TNBC标本147 例，通过免疫组化检测其MMP9、P53的表达。结合临床随访数据，分析MMP9、P53 的表达与
TNBC 预后的关系。结果：TNBC占同期本院收治的乳腺癌13.3%(147/1103)。MMP9、P53 在TNBC中的阳性表达率分别为47.6%
和66.0%。MMP9 与TNBC患者的淋巴结转移数显著相关(P=0.003)。MMP9表达阳性的TNBC 与MMP9 表达阴性TNBC 患者
60 个月的无病生存(disease free survival，DFS)率分别为62%和83%，差异具有统计学意义(P=0.001)；总体生存率(overall survival，
OS)率分别为66%和73%，差异具有统计学意义(P=0.022)。P53表达阳性的TNBC 和P53 表达阴性的TNBC 患者60个月的DFS
分别为65%和87%(P=0.010)；OS分别为60%和85%(P=0.005)。MMP9和P53 的HR 分别为3.353(95%CI：1.614-6.966，P=0.001)和
2.979 (95%CI:1.239-7.165，P=0.015)。结论：MMP9 和P53在TNBC 中的阳性表达与患者的预后不良有关，且MMP9 为影响TNBC
患者预后的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the expression of MMP9 (matrix metal proteinase 9, MMP9) and P53 in TNBC (triple
negative breast cancer, TNBC) ,and their relationship with the prognosis of TNBC. Methods:147 cases of TNBC Paraffin specimens with
complete clinical data which were treated in General Surgery Department, Affiliated Xinhua Hospital of Shanghai Jiaotong from March
2002 to July 2011 were collected. Expression of MMP9 and P53 were detected by immunohistochemistry. Combined with clinical
follow-up data, the relationship between expression of MMP9/ P53 and TNBC prognosis was studied. Results: In 1103 cases of breast
cancer, 147 cases were TNBC (13.3%). The positive expression rate of MMP9 and P53 in TNBC were 47.6% and 66.0% respectively.
MMP9 expression was associated with the number of metastasizing lymph nodes (P=0.003). The 60 months DFS (disease free survival
rate) of TNBC patients with positive and negative MMP9 expression were 62%and 83%respectively,(P=0.001) and OS (Overall survival
rate) were 66%and 73%(P=0.022) . The 60 months DFS of TNBC patients with positive and negative P53 expression were 65%and 87%
respectively (P=0.010), and OS were 60%and 85%(P=0.005) . The hazard ratio of metastasis or recurrence for the status of MMP9 and
P53 were 3.353 (95%CI：1.614-6.966, P=0.001) and 2.979 (95%CI:1.239-7.165,P=0.015) respectively. Conclusion:The upregulation of
MMP9 and P53 expression were associated with the poor prognosis of patients with TNBC, and MMP9 was an independent risk factor.
high expression of MMP9 and P53 indicated poor prognosis in TNBC. |
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