| 刘剑尚鑫沙素梅夏丽敏吴开春△.转录因子FOXP1 在胃癌组织中的表达及意义*[J].,2014,14(5):814-818 |
| 转录因子FOXP1 在胃癌组织中的表达及意义* |
| Expression and Significance of Forkhead Box P1 in the Tissuesof Gastric Cancer* |
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| DOI： |
| 中文关键词: FOXP1 蛋白 胃癌 免疫组织化学 抑癌基因 |
| 英文关键词: Forkhead box P1(FOXP1) Gastric cancer Immunohistochemistry Tumor suppressor gene |
| 基金项目:国家重点基础研究发展计划"973 项目"(2010CB529302)；国家自然科学基金项目(81272652；81172290；91129723) |
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| 中文摘要: |
| 摘要目的：检测FOXP1 蛋白在胃癌组织及癌旁正常组织中的表达情况，并探讨其与胃癌患者病理参数及预后的关系。方法：采
用免疫组织化学染色方法检测90例胃癌组织和相应癌旁正常组织中FOXP1 的表达情况并进行评分，进一步统计分析FOXP1
表达与胃癌患者临床病理参数以及预后的关系。结果：FOXP1 在胃癌组织中的表达显著低于癌旁正常组织（P<0.01）；对临床资料
进行统计分析表明，在临床III 期和IV期患者的胃癌组织中FOXP1 的表达显著低于临床I期和II 期的患者（P<0.05）；FOXP1 在
低分化胃癌中的表达显著低于高、中分化胃癌（P<0.01）；FOXP1 表达阳性者术后总体生存率较表达阴性者高(P=0.145)，中位生存
期长。结论：FOXP1 表达的减少可能参与了胃癌的发生发展，FOXP1 在胃癌中可能扮演抑癌基因的角色，FOXP1可作为胃癌治疗
的潜在靶点。 |
| 英文摘要: |
| ABSTRACT Objective:To investigate the expression and clinical significance of Forkhead box P1(FOXP1) protein in gastric cancer
tissues and adjacent non-tumor tissues.Methods: Immunohistochemistry was used to detect the expression of FOXP1 in 90 gastric cancer
tissues and paired adjacent non-tumor tissues. Statistic analyses were explored to value its correlation with the clinicopathological
characteristics and prognosis.Results: FOXP1 expression was significantly decreased in gastric cancer tissues compared with the
corresponding adjacent non-tumor tissues (P<0.01). Further analysis about its correlation with the clinicopathological characteristics
showed that FOXP1 expression was significantly lower in patients of clinical III-IV stage than in I-II stage (P<0.05). The expression of
FOXP1 was significantly lower in poorly differentiated gastric cancer than in moderately and well differentiated gastric cancer (P<0.01).
Patients with FOXP1 positive expression had a better prognosis and longer median survival time than those with negative expression
(P=0.145). Conclusion:The decreased FOXP1expression may contribute to gastric cancer initiation and progression. FOXP1 may play
its role as a tumor suppressor in gastric cancer. FOXP1 is a potential therapeutic target in gastric cancer. |
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