| 段新辉 王蓉 徐超 李晓军 申静 王宏.脑梗死患者内脂素和基质金属蛋白酶-9 与颈动脉粥样硬化
斑块易损性的关系[J].,2014,14(3):500-502 |
| 脑梗死患者内脂素和基质金属蛋白酶-9 与颈动脉粥样硬化
斑块易损性的关系 |
| The Relationship of SerumVisfatin and MMP-9 with the Vulnerability ofCarotid Atherosclerotic Plaque in Ischemic Cerebrovascular Disease |
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| DOI： |
| 中文关键词: 内脂素 基质金属蛋白酶-9 脑梗死 颈动脉粥样硬化 易损性 |
| 英文关键词: Visfatin Matrix metalloproteinase-9 Brain infarction Atherosclerosis Vulnerability |
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| 中文摘要: |
| 目的：探讨血清内脂素（Visfatin）及基质金属蛋白酶-9（MMP-9）水平与脑梗死患者颈动脉粥样硬化斑块稳定性的关系和血
清visfatin 和MMP-9 的相关性。方法：选择脑梗死患者70 例，根据颈动脉粥样硬化斑块性质分为易损性斑块组(n=43)和非易损
性斑块组(n=27)，选取健康体检者30 例作为对照组。测定血清Visfatin 和MMP-9 水平，并对二者间关系进行相关分析。结果：脑
梗死伴颈动脉硬化组血清Visfatin、MMP-9 水平高于正常对照组(P＜0.01)；易损性斑块组血清Visfatin 和MMP-9 水平高于非易
损性斑块组，差异有统计学意义（P＜0.017）。外周血中的Visfatin水平与MMP-9 呈正相关关系（r=0.643，P=0.000）。结论：在脑梗
死患者中，血清Visfatin和MMP-9 参与了颈动脉粥样硬化的病理生理过程，Visfatin 和MMP-9升高可能与颈动脉粥样硬化斑块
不稳定性的形成相关，Visfatin 可通过调控MMP-9 的分泌和活性从而改变斑块的易损性。 |
| 英文摘要: |
| Objective:To explore the relationship of Visfatin and MMP-9 with the vulnerability of carotid atherosclerotic plaque
and the correlation of serum Visfatin and MMP-9.Methods:According to the carotid atherosclerosis plaque vulnerability, 70 patients
with cerebral infarction were divided into vulnerable plaque group (n=43) and unvulnerable plaque group (n=27). Thirty healthy subjects
were selected as controls (control group). The levels of serum Visfatin and MMP-9 were examined, and analyse the correlation between
them.Results:The level of Visfatin and MMP-9 in the Cerebral infarction associated with carotid atherosclerosis group was significantly
higher than that in control group (P＜0.01). The level of Visfatin and MMP-9 in the vulnerable plaque group was higher than that in the
unvulnerable plaque group and control group (P＜0.017). A positive correlation was observed between the expression of Visfatin and
MMP-9 in vitro (r=0.643, P=0.000).Conclusion:The serumVisfatin and MMP-9 participated in the pathophysiological process of carotid
atherosclerosis in cerebral infarction patients, it may be correlation high levels of Visfatin and MMP-9 with the formation of caotid
atheroscleotic plaque instability, Visfatin may be regulate MMP-9 secretion and activity, which changes plaques vulnerability. |
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