| 李扬龚 钱嫦云 陆菲 徐晓芬 沈园园.载紫杉醇共聚物胶束的合成与表征[J].,2014,14(3):441-443 |
| 载紫杉醇共聚物胶束的合成与表征 |
| Preparation and Characterization of Paclitaxel-loaded Polymeric Micelles |
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| DOI： |
| 中文关键词: 开环聚合 载药量 固体分散- 超声法 包封率 |
| 英文关键词: Ring-opening polymerization Drug loading Solid dispersion-sonication Encapsulation efficiency |
| 基金项目:国家自然科学基金项目（81171439/H1816） |
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| 中文摘要: |
| 目的：制备一种包封率、载药量高的紫杉醇载体材料。方法：开环聚合法一步合成了两种两亲性共聚物PTL1 和PTL2,以核
磁和凝胶渗透色谱进行了产物的表征,以固体分散- 超声法制备紫杉醇胶束，考察了胶束的载药量、包封率。结果：核磁和凝胶渗
透色谱的结果显示得到了目标产物，所制备得到的载紫杉醇胶束包封率可以达到90%以上，载药量为9.5%以上。结论：实验结果
表明我们所合成的PTL1 和PTL2 是好的紫杉醇载体材料。 |
| 英文摘要: |
| Objective:To obtain a high loading and encapsulation efficiency micellar carrier of paclitaxel.Methods:Amphiphilic
block copolymers PTL1 and PTL2, were synthesized by ring-opening polymerization and their compositon were characterized by
1H-NMR and GPC. Paclitaxel micelles were prepared through solid-dispersion-sonication method. The drug loading and encapsulation
efficiency of the micelles were investigated.Results:PTL1 and PTL2 were successfully synthesized The drug loading contents of
micelles were higher than 9.5% and the encapsulation efficiency were high than 90%.Conclusion:PTL1 and PTL2 could be promising
paclitaxel micellar carriers. |
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