| 韩燃1 房华丽2 郭峰2 廖鹏运1 李锐1 李文平1△.EHEC 的新型粘附因子研究进展*[J].,2014,14(2):372-376 |
| EHEC 的新型粘附因子研究进展* |
| Initial Adherence of EHEC* |
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| DOI： |
| 中文关键词: 肠出血性大肠杆菌 粘附因子 粘附作用 |
| 英文关键词: Enterohemorrhage Adhesion Adherence |
| 基金项目:国家自然科学基金项目（81072677）；北京自然科学基金项目（7122134） |
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| 中文摘要: |
| 摘要：肠出血性大肠杆菌（enterohemorrhage ，EHEC）是一种重要的人畜共患病，世界各地包括中国都有不同规模的暴发流
行。EHEC有多种血清型，其中毒力最强血清型是O157：H7。EHEC O157：H7 感染除可使人发生常规腹泻外，还可在5%-10%的病
例中引发严重并发症，甚至死亡。该菌是重要的食源性致病菌，危害严重，缺乏有效的防治手段，而抗生素治疗可能会加剧溶血性
尿毒症（haemolutic uraemic syndrome，HUS）。由于以上特点EHEC O157：H7 成为世界公共卫生问题，引起微生物学家和公共卫生
工作者的广泛关注。目前，临床针对EHEC 感染只是对症治疗和适当的抗菌治疗。粘附是EHEC感染宿主细胞的第一步，没有这
一步，细菌和宿主肠道细胞之间不会发生任何的相互作用，而且对于许多病原菌来说，粘附具有宿主特异性。本文概述了EHEC
的流行病学及粘附机理，并对近年在EHEC 研究中的发现一些新型粘附因子和一些假设的定植因子的研究背景及作用机理作一
综述。 |
| 英文摘要: |
| Enterohaemorrhagic (EHEC) are emerging zoonotic pathogens, different countries including China
had reported different scale of outbreak and sporadic cases. EHEC have many serotypes, O157:H7 is the most virulent. Human infection
is associated with a wide range of clinical illness, including asymptomatic shedding, and about 5%-10% develops to bloody diarrhea,
haemorragic colitis, haemolytic uraemic syndrome, and even death. EHEC O157:H7 is found regularly in the faeces of healthy cattle, and
is transmitted to humans through contaminated food, water, and direct contact with infected people or animals. Treatment of EHEC
O157:H7 infection with antimicrobial agents is controversial, and management of patients is only supportive, because antimicrobial
agents may increase the risk of HUS. During the past decade, EHEC O157:H7 has evolved from a clinical novelty to a global
public-health concen. Initial adherence to host cells is the first step of the infection of EHEC. Adherence is the first contact between
bacteria and intestinal cells without which the other steps cannot occur, and adherence is the basis of host specificity for a lot of
pathogens. The aim of this review is to describe the epidemiology and adherence mechanismof enterohemorrhage (EHEC), and to
summarize several new adhesions and putative colonization factors have found in EHEC during the last few years. |
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