| ABSTRACT Objective：To observe the clinical effect of mechanical ventilation combined with ulinastatin in treatment of acute
respiratory distress syndrome.Methods： Date of Sixty patients with acute respiratory distress syndrome were retrospectively analyzed,
treatment group (30 cases) were treated using mechanical ventilation combined with ulinastatin; control group (30 cases) were treated
using mechanical ventilation, then the respiratory frequency, PaO2, PaO2/FiO2, PCO2, APACHEII scores, chest radiograph change, VAP
incidence and mortality in the two groups were observed. Results：Respiratory frequency, PaO2, PaO2 /FiO2 and PCO2 in treatment group
were better than those in control group (t=6.39, 6.27, 24.07, 9.82，P<0.05); VAP incidence was 20.0%in treatment group, and was less
than 36.7%in control group ( X2 =5.84, P=0.016<0.05); mortality (3.3%) in treatment group was less than 16.7%in control group (X2=
5.71, P=0.017<0.05). APACHEII scores and chest X-ray changes between the two groups had obvious difference (t=7.14, 6.33, P < 0.05).
Conclusion：The clinical effect of mechanical ventilation combined with ulinastatin in treatment of acute respiratory distress syndrome is
good; the treatment can improve lung function, alleviates the symptoms, improves the safety and reliability and controls the mortality. |
