| 木亚斯沙尔王英帕里·加帕尔张玲董俊杰.老年急性脑梗塞患者血清TNF-α 和IL-6 水平的变化及其临床意义[J].,2012,12(27):5327-5329 |
| 老年急性脑梗塞患者血清TNF-α 和IL-6 水平的变化及其临床意义 |
| The Serum TNF-α and IL-6 Level Changes and its Clinical Significancein the Elderly Patients with Acute Cerebral Infarction |
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| DOI： |
| 中文关键词: 老年 急性脑梗塞 TNF-α IL-6 临床意义 |
| 英文关键词: The elderly Acute cerebral infarction TNF-alpha IL-6 Clinical significance |
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| 中文摘要: |
| 目的：观察老年急性脑梗塞(ACI)患者血清TNF-α 和IL-6 水平的变化并探讨其临床意义。方法：选择老年ACI 患者53 例，
观察以上入选患者入院后第7d、第9d 和第11d 血清TNF-α 和IL-6 水平的变化，并与26 例健康人对照；同时分析53 例老年ACI
患者血清TNF-α 和IL-6 水平与患者脑梗塞面积及神经功能缺损评分的Spearman 等级相关性。结果：老年ACI 患者血清TNF-α
和IL-6 水平显著高于健康人(P＜0.01)；随着治疗的进展与病情的稳定及恢复，患者血清TNF-α 和IL-6 水平随之显著下降(P＜
0.05)；同时患者血清TNF-α 和IL-6 水平与病变的严重程度呈正相关性(P＜0.05)；治疗11d 后血清TNF-α 和IL-6 降低量与病变
的严重程度呈正相关性(P＜0.05)。结论：在老年ACI 患者治疗过程中，应进行血清TNF-α 和IL-6 水平的动态监测，可提示病变
的发生发展并指导临床治疗。 |
| 英文摘要: |
| Objective: To observe the serum TNF-α and IL-6 level changes and discuss its clinical significance in the elderly
patients with acute cerebral infarction. Methods: Collect 53 elderly patients with acute cerebral infarction, observe the serum TNF-α and
IL-6 level changes the 7th day, the 9th day and the 11th day after admission and compare with 26 healthy people;analysis the correlation
analysis of serum TNF-α and IL-6 levels with disease severity. Results: The elderly patients' TNF-α and IL-6 level were statistical higher
than the healthy people's(P＜0.01); the serum TNF-α and IL-6 levels significantly decreased (P <0.05) with the progress of treatment;the
aerum TNF-α and IL-6 levels were positively correlated (P <0.05) with the disease severity, the aerum TNF-α and IL-6 levels' reduction
were positively correlated (P <0.05) with the disease severity after 11days' treatment. Conclusion: In the course of treating elderly patients
with ACI,we should dynamic monitor the serum TNF-α and IL-6 levels,it could prompt the development of the lesions and guide the
clinical treatment. |
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