| 王霞周江睿蒋春雷△.神经肽的免疫调节作用[J].,2012,12(26):5189-5191 |
| 神经肽的免疫调节作用 |
| Neuropeptide Regulation of Immunity |
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| DOI： |
| 中文关键词: 神经肽Y 炎症 免疫 cAMP-PKA |
| 英文关键词: Neuropeptide Inflammation Immunity cAMP-PKA |
| 基金项目: |
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| 摘要点击次数: 900 |
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| 中文摘要: |
| 机体自我免疫耐受的降低或者破坏会导致免疫系统的失衡，并加重炎症反应过程，从而引发多种自身免疫性疾病。所以诱
导免疫耐受并终止炎症反应对恢复机体健康具有十分重要的意义。最近研究发现机体在炎症反应过程中会释放一类神经肽，如
VIP, urocortin, ghrelin等。这些神经肽可下调固有免疫应答，抑制抗原特异性Th 1 细胞分化，诱导调节性T细胞的产生，维持免疫
耐受，并终止炎症反应。神经肽的这种抑炎作用主要是通过激活cAMP-PKA通路以及调节与免疫炎症因子表达相关的信号通路
来实现的。神经肽有可能成为治疗炎症性疾病的一类新药物。 |
| 英文摘要: |
| The loss of immune tolerance results in the breakdown of immune homeostasis and the appearance of exacerbated
inflamematory conditions, causing a variety of autoimmune disease. Induction of immune tolerance and resolution of inflammation are
essential to health. Some neuropeptides such as VIP, urocortin, ghrelin, are produced during the ongoing inflammatory response. Those
neuropeptides could downregulation innate immunity, inhibit antigen-specific Th1-driven responses and generate regulatory T cells.
Therefore, they participate in maintaining immune tolerance and resolving inflammation. The effects of these neuropeptides in
anti-inflammatory activity depend on the activation of cAMP-protein kinase A signaling and the regulation of various transduction
pathways involved in the expression of many immune factors. Neuropeptides maybe become a novel pharmacological agents for the
treatment of immune disorders. |
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