| 姚晴宇许著一孙杨马涛徐德恩.多系统萎缩的早期综合诊断[J].,2012,12(26):5117-5119 |
| 多系统萎缩的早期综合诊断 |
| Early Comprehensive Diagnosis in Multiple System Atrophy |
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| DOI： |
| 中文关键词: 多系统萎缩 磁共振成像 Shy-Drager综合征 橄榄体脑桥小脑萎缩 黑质纹状体变性 |
| 英文关键词: MSA MRI Shy-Drager syndrome Olivopontocerebellar atrophy Striatonigral degeneration |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨多系统萎缩(multiple system atrophy，MSA)患者的临床表现及神经影像学新特征(脑桥“十字征”和“壳核裂隙征”)
在MSA早期诊断中的临床意义。方法：回顾性分析21 例临床诊断为多系统萎缩（MSA）患者的临床表现和头部MRI资料。结
果：21例MSA患者中，Shy-Drager综合征（MSA-A）9例，早期临床表现为体位性低血压，泌尿生殖功能障碍，头部MRI检查脑桥
“壳核裂隙征”和“十字征”为Ⅰ期；橄榄体脑桥小脑萎缩(MSA-C)5 例，3 例发病后1 年头部MRI脑桥“十字征”达Ⅱ期；“壳核裂隙
征”为Ⅰ期，2例发病后3年头部MRI脑桥“十字征”达Ⅳ期。黑质纹状体变性(MSA-P)7例：早期临床均有运动迟缓、震颤等表现，
3例发病后1年脑桥“十字征”Ⅰ期，“壳核裂隙征”Ⅲ期；3 例发病后2 年脑桥“十字征”Ⅰ期，“壳核裂隙征”Ⅰ期；另1 例发病后9
月脑桥“十字征”Ⅰ期，“壳核裂隙征”Ⅱ期。结论：认为临床表现与头部MRI检查显示的新的影像学特征结合有助于MSA 早期
诊断。 |
| 英文摘要: |
| Objective: To analyze the clinical manifestations as well as correlation between clinical manifestations and the new
neuroimage characteristics (pontine"cross sign"and "putaminal slit")for early diagnosis of MSA. Methods:21 patients with diagnostic as
multiple system atrophy (MSA) were retrospectively an analyzed for clinical manifestations and brain MRI findings．Results:In 21
patients with MSA，9 patients were MSA-A, eariy clinical manifestations of orthostatic hypotension,urogenital dysfunction, MRI showed
stage Ⅰ"Cross sign "and" putaminal slit". 5 patients were MSA-C, early clinical appear unstable walking,ataxia and other performance,
MRI showed stage Ⅱ"Cross sign "and stage Ⅰ" putaminal slit"after onset.7 patients were MSA-P,early clinical are bradykinesia,tremor
and other performance,3 patients reached stage Ⅰ"Cross sign "and stage Ⅳ" putaminal slit" one years after onset, 3 patient reached stage
Ⅰ"Cross sign "and stage Ⅰ" putaminal slit"two years after onset, another patient reached stage Ⅰ"Cross sign "and stage Ⅱ" putaminal
slit" nine months after onset. Conclusions:Clinical manifestations and the new neuroimage characteristics were very important for early
diagnosis of MSA. |
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