| 丁山陈辉骆健明郭燕春林岚谢泽宇.人脑胶质瘤中热休克蛋白70、Caspase-3 的表达及临床意义[J].,2012,12(26):5088-5090 |
| 人脑胶质瘤中热休克蛋白70、Caspase-3 的表达及临床意义 |
| The Expression and Clinical Significance of HSP70 and Caspase-3in Gliomas |
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| DOI： |
| 中文关键词: 脑胶质瘤 热休克蛋白70 Caspase-3 免疫组织化学 |
| 英文关键词: Gliomas Heat-shock 70 Cyserinly aspartate-specific protease 3 Immunohistochemistry |
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| 中文摘要: |
| 目的：探讨热休克蛋白70、caspase-3 在人脑胶质瘤中的表达和临床意义。方法：收集2008 年7 月～2010 年12 月汕头大学
医学院第二附属医院神经外科手术获取的人脑胶质瘤组织标本35 例，另选择20 例脑外伤手术中切除的正常脑组织标本作为对
照组。采用EnVision免疫组化方法检测脑胶质瘤组织和正常脑组织中热休克蛋白70、caspase-3 的表达，并分析其与脑胶质瘤组
织临床病理特征之间的关系。结果：HSP70在胶质瘤组和对照组中的阳性表达率分别为74.3％和25.0％，胶质瘤组的HSP70表达
明显高于对照组(P<0.05)。caspage-3 在胶质瘤组和对照组中的阳性表达率分别为34.3％和80.0％，胶质瘤组的caspage-3 阳性表
达率均明显低于对照组(P<0.01)。HSP70和caspase-3 的阳性表达与胶质瘤的病理学分级、术后复发情况密切相关(P<0.05)。相关分
析表明，胶质瘤组织中HSP70阳性表达率和caspase-3 表达呈负相关(r=-0.568，P<0.05)。结论：胶质瘤组织中HSP70 呈高表达,而
caspase-3 表达下调，两者均在胶质瘤浸润、复发等恶性演进过程中发挥重要作用；HSP70 可能通过某些途径抑制caspase-3 表达
来抑制胶质瘤恶性细胞的凋亡发生。 |
| 英文摘要: |
| Objective: To investigate the expression and clinc significance of HSP70 and caspase-3 in gliomas. Methods: The
expression of HSP70 and caspase-3 protein was detected with immunohistochemical EnVision plus non-hiotin technique in 35 cases of
gliomas and 20 cases of normal cerebral tissue. The correlation with clinicopathologic characteristic were analyzed. Results: The positive
expression rates of HSP70 protein in gliomas(74.3%) were significantly higher than that in normal cerebral tissue(25.0%) and the positive
expression rates of caspase-3 protein in gliomas(34.3%) were significantly lower than that in normal cerebral tissue(80.0%) (P<0.01). The
expression of HSP70 and caspase-3 were positively related to tumor clinica1 s tage and recurence (P< 0.01). HSP70 expression was
negatively correlated with caspase-3 (r=-0.568，P<0.05). Conclusion: HSP70 showed high expression and the expression of caspase-3
decreased in gliomas. HSP70 and caspase-3 play an important role in metascasis and recurence in gliomas．HSP70 inhibites apoptosis
control of tumor cells of gliomas through inhibiting the expression of caspase-3. |
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