| 周艳贤郭晓东冯卉陈敏刘阳董晓宇.超声弹性成像评价肝纤维化程度的探讨[J].,2012,12(26):5072-5074 |
| 超声弹性成像评价肝纤维化程度的探讨 |
| Investigation of Ultrasound Elasticity Imaging in Evaluatingthe Degree of Liver Fibrosis |
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| DOI： |
| 中文关键词: 实时组织弹性成像 肝纤维化 肝组织活检 实验室检查 |
| 英文关键词: Real-time elastography imaging Liver fibrosis Liver biopsy Laboratory tests |
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| 中文摘要: |
| 目的：运用实时组织弹性成像（RTE）对肝脏弹性图像进行评分，并通过与实验室指标的比较，探讨RTE 评分诊断肝纤维化
程度的可行性与准确性。方法：选取我院收治的慢性病毒性肝炎患者90例作为研究对象，行RTE以及肝功能、血常规和凝血五项
等实验室检查，随后肝活检获得病理学证据。比较RTE评分与实验室指标诊断肝纤维化程度的准确性。结果：90 例患者中，S0期
21例，S1期31例，S2期31例，S3期20例，S4期7例。RTE评分与肝纤维化程度呈正相关(r=0.79，P<0.05)。同样，门冬氨酸氨基
转移酶／血小板比例指数(APRI)与肝纤维化程度也呈正相关(r=0.57，P<0.05)。RTE 评分只与APRI 呈相关性(r=0.667，P=0.000)。
RTE 评分诊断明显肝纤维化的敏感度为94.31％、特异度为78.65％、准确率为85.22％、阳性预测值为76.63％、阴性预测值为
94.58％，均高于APRI。结论：实时组织弹性成像技术在诊断肝纤维化方面有广泛的临床研究价值和前景。 |
| 英文摘要: |
| Objective: The purpose of the present study is to grade the liver elasticity image with real-time elastography imaging
(RTE), and explore the feasibility and accuracy of diagnosis of liver fibrosis with the RTE score by the comparison with the laboratory
indicators. Methods: Ninety patients with chronic viral hepatitis in our hospital were enrolled in the present study. RTE, liver function,
blood routine, and five laboratory tests were tested. Then, liver biopsy were applied for pathological evidence. The accuracy of the
diagnosis of liver fibrosis by RTE scores and laboratory indicators were compared. Results:Among the 90 patients, 21 cases were S0, 31
cases S1, 31 cases S2, 20 cases S3, and 7 cases were S4. RTE score was positively correlated with the degree of hepatic fibrosis (r = 0.79,
P <0.05). Also, aspartate aminotransferase to platelet ratio index (APRI) was positively correlated with the degree of hepatic fibrosis (r =
0.57, P <0.05). RTE score was only correlated with APRI (r = 0.667, P = 0.000). In the RTE score, the sensitivity of the diagnosis of
significant liver fibrosis was 94.31%, the specificity was 78.65% , the accuracy rate was 85.22%, positive predictive value was 76.63%,
and the negative predictive value was 94.58%, all of which were higher than those in APRI. Conclusion:Real-time elastography imaging
has promising prospect and extensive clinical value in the diagnosis of liver fibrosis. |
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