| 吴恩应张佩张运佳丁玉江郭采平△.人巨细胞病毒IgG 抗体标准品研究进展[J].,2012,12(25):4970-4972 |
| 人巨细胞病毒IgG 抗体标准品研究进展 |
| The State of International Standard Material for CytomegalovirusImmunoglobulin G Determinations |
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| DOI： |
| 中文关键词: 人巨细胞病毒 人巨细胞病毒免疫球蛋白G 抗体 标准品 |
| 英文关键词: Cytomegalovirus Anti-Cytomegalovirus immunoglobulin G Standard material |
| 基金项目:广东省中国科学院全面战略合作项目" 病毒感染重症救治特效抗体药物技术及产品研发"(2009B091300101) |
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| 中文摘要: |
| 人巨细胞病毒(CMV)是威胁人类健康的最重要病原之一。高CMV 抗体效价的免疫球蛋白G（IgG）制剂，为临床医生在预防
和治疗用药上提供了一个有价值的选择。而CMV 免疫球蛋白标准品对于制品的CMV 抗体效价测定以及高效价血浆的筛选都
至关重要。该标准品对于器官移植/ 输血安全测试，以及临床诊断都是不可或缺。本综述提供了一种人巨细胞病毒IgG 标准品制
剂方法以及目前研究进展的概述。此外，本文还关注应用于不同领域的不同CMV IgG 抗体效价单位。故本文为人巨细胞病毒免
疫球蛋白的开发，人巨细胞病毒IgG 抗体诊断试剂的标准化，以及为其质量控制提供参考。 |
| 英文摘要: |
| Cytomegalovirus (CMV) remains one of the most important pathogens threatening health of people. Immunoglobulin
G (IgG) preparations with high antibody titers against CMV are valuable adjunctive prevention and treatment option for clinicians. The
anti-CMV immunoglobulin standard is critical for CMV antibody titer quantification of these preparations and selection of high titer plasma.
It is also required in testing for both transplantation/transfusion safety and clinical diagnostic purposes. This review provides a summary
of the process and current state of anti-Cytomegalovirus IgG standard material preparations. Besides, it sheds a light on the different
titer units of anti-Cytomegalovirus immunoglobulin G used in different conditions. Therefore, this paper would give a review on development
of anti-Cytomegalovirus immunoglobulin, the standardization and of diagnostics reagents for anti-Cytomegalovirus IgG and their
quality control. |
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