| 范滨1 唐金海2△ 吴建中3 王卓3 薛琏3.南京地区青年乳腺癌患者GSTM1、GSTT1 基因多态性与易感性
的初步研究[J].,2012,12(25):4813-4815 |
| 南京地区青年乳腺癌患者GSTM1、GSTT1 基因多态性与易感性
的初步研究 |
| A Preliminary Study on the Relationship between Genetic Polymorphism ofGlutathione-S transferases T1, M1genes and Susceptibility of Young FemaleBreast Cancer in Nanjing Area* |
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| DOI： |
| 中文关键词: 乳腺癌 GSTM1 GSTT1 基因多态性 |
| 英文关键词: Breastcancer GSTM1 GSTT1 Genetic polymorphism |
| 基金项目:国家自然科学基金项目（30840093）；江苏省社会发展科技计划项目（BS2007077） |
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| 中文摘要: |
| 目的：研究GSTM1、GSTT1 基因多态性与乳腺癌遗传易感性的关系。方法：应用PCR 技术检测乳腺癌组和对照组人群
GSTM1 和GST T1 基因。结果：GSTM 1 和GSTT 1 基因缺失率在乳腺癌组分别为63. 4%(59/ 93)和54. 8%(51/ 93) ,对照组分别为
39.3% (35/ 89) 和33.7% (30/89) , 两组比较,差异有统计学意义(P<0.01 或P<0.05)。结论：GSTM1 和GST T1 缺失为乳腺癌遗传易
感因素。 |
| 英文摘要: |
| Objective: To examine the relationship of genetic polymorphisms of glutathione S-transferase (GST) including GSTM1
and GSTT1 and the susceptibility to breastcancer. Methods: A case-control study was designed and the absence of GSTM1 and GSTT1
genes were detected with PCR technique in 93 cases and 89 conrols. Results: The results showed that the ratios of GSTM1 null genotype
in cases was 63. 4%(59/ 93) and the ratios of GSTT1 null genotype in cases was 54. 8%(51/93), while, those of controls were 39.3% (35/
89) or 33.7% (30/89), P< 0.05. Conclusion: GSTM1 and GSTT1 null may be an important host risk factor for breastcancer. |
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