| 赵兴会周晓光赵霞朱文秀韩世愈.恶性肿瘤中人绒毛膜促性腺激素β 亚单位的研究进展[J].,2012,12(24):4773-4776 |
| 恶性肿瘤中人绒毛膜促性腺激素β 亚单位的研究进展 |
| Progress in Study on Expression of βhCG in Malignant Tumors |
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| DOI： |
| 中文关键词: βhCG 恶性肿瘤 |
| 英文关键词: βhCG Malignant tumor |
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| 中文摘要: |
| 人绒毛膜促性腺激素是一种糖蛋白激素。在妊娠期主要由胎盘合体滋养层细胞分泌产生，在非妊娠情况下，机体内含量极
微。目前发现几乎所有组织，尤其是肿瘤包括乳腺癌、子宫颈癌、卵巢癌、膀胱癌等均可产生人绒毛膜促性腺激素β 亚单位。人绒
毛膜促性腺激素对胎盘和生殖细胞起源的滋养细胞肿瘤是一个非常敏感和特殊的肿瘤标志物。很多非滋养细胞肿瘤只产生
βhCG，而这是侵袭性疾病的标志，血清中提高的βhCG 水平是和肿瘤的不良预后相联系的。 |
| 英文摘要: |
| Human chorionic gonadotuopin (hCG)is a glycoprotein hormone. It is mainly secreted by placental syntrophohlastic
cells during pregnancy. In non-pregnanay period, there is few hCG in body. At present βhCG has been found in almost all tissues especially
tumor tissues including mammary cancer, cervical carcinoma, ovarian carcinoma, bladder carcinoma etc. Human chorionic gonadotropin
is an extremely sensitive and specific marker for trophoblastic tumors of placental and germ cell origin. Many nontrophoblastic
tumors only produce hCGβ, This is usually a sign of aggressive disease and elevated serum levels of hCGβ which is strongly
associated with poor prognosis. |
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