| 秦石李义光刘义王伟赵红宋乐.冠心病患者血清尿酸、高敏C 反应蛋白、纤维蛋白原水平变化
的临床研究[J].,2012,12(22):4291-4293 |
| 冠心病患者血清尿酸、高敏C 反应蛋白、纤维蛋白原水平变化
的临床研究 |
| Clinical Analysis of Serum Uric Acid, High Sensitivity C Reactive Proteinand Fibrinogen in Patients with Coronary Heart Disease |
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| DOI： |
| 中文关键词: 冠心病 尿酸 高敏C 反应蛋白 纤维蛋白原 |
| 英文关键词: Coronary heart disease Uric acid High sensitivity C reactive protein Fibrinogen |
| 基金项目: |
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| 中文摘要: |
| 目的：观察冠心病患者血清中尿酸、高敏C 反应蛋白、纤维蛋白原水平的变化。方法：选取2010 年11 月至2011 年11 月于
我院就诊的68 例冠心病患者(稳定型心绞痛21 例，不稳定型心绞痛24 例，急性心肌梗死13 例)作为研究对象，并选取同期于我
院体检中心体检的62 例健康人为对照组，检测受试者血清中尿酸、高敏C 反应蛋白、纤维蛋白原的水平。结果：研究组患者血清
中UA、CRP 和FBG 水平显著高于对照组(P<0.05)。与稳定型心绞痛组比，不稳定型心绞痛的CRP 水平增高(5.34±1.98 mg/L vs.
11.36±2.73 mg/L, P<0.05)，急性心肌梗死组的UA (345.63 ±86.4 μmol/L vs. 493.76 ±101.2 μmol/L, P<0.05)、CRP (5.34 ±1.98
mg/L vs. 21.3 ±2.24 mg/L, P<0.05)和FBG(3.86 ±1.34 g/L vs. 6.85 ±2.36 g/L, P<0.05)水平显著增高，与不稳定型心绞痛组比，急
性心肌梗死组的UA(378.91±89.7 μmol/L vs. 493.76±101.2 μmol/L, P<0.05)、CRP(11.36±2.73 mg/L vs.21.3±2.24 mg/L, P<0.05)
和FBG(4.27±2.08 g/L vs. 6.85 ±2.36 g/L, P<0.05)水平显著增高(P<0.05)。结论：冠心病患者血清中尿酸、高敏C 反应蛋白和纤维
蛋白原的水平升高，3 个指标可用于评估治疗效果和预后。 |
| 英文摘要: |
| Objective: To investigate the clinical significance of serum uric acid, high sensitivity C reactive protein and fibrinogen
in patients with coronary heart disease. Methods: 68 coronary heart disease patients who were treated in our hospital from Nov, 2010 to
Nov, 2011 were enrolled in our research:21 stable angina pectoris, 24 unstable angina pectoris and 13 acute myocardial infarction. And
68 normal persons who received physical examination in our hospital in the same time were also selected in this research as control.
Serum uric acid, high sensitivity C reactive protein and fibrinogen of the patients and control were detected. Results: Compared with
control, serum uric acid, high sensitivity C reactive protein and fibrinogen in patients with coronary heart disease were significantly
higher than control (P<0.05). Compared with stable angina pectoris, hs-CRP were much higher in unstable angina pectoris patients
(5.34±1.98 mg/L vs.11.36±2.73 mg/L, P<0.05) , UA (345.63 ±86.4 μmol/L vs. 493.76 ±101.2 μmol/L, P<0.05), CRP (5.34±1.98
mg/L vs.21.3±2.24 mg/L, P<0.05)and FBG (3.86 ±1.34 g/L vs. 6.85 ±2.36 g/L, P<0.05)were higher in acute myocardial infarction
patients.Compared with unstable angina pectoris, UA (378.91±89.7 μmol/L vs. 493.76±101.2 μmol/L, P<0.05), CRP (11.36 ±2.73
mg/L vs.21.3±2.24 mg/L, P<0.05) and FBG (4.27±2.08 g/Lvs. 6.85 ±2.36 g/L, P<0.05) were significantly higher in acute myocardial
infarction patients. Conclusion: Serum levels of uric acid, high sensitivity C reactive protein and fibrinogen in coronary heart disease
were elevated, and these three markers were closely related to treatment of coronary heart disease. |
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