| 韩光炜江继宏黄丽娜李士通△.罗库溴铵和顺式阿曲库铵持续输注对机械通气SD 大鼠膈肌功能
的影响[J].,2012,12(22):4220-4224 |
| 罗库溴铵和顺式阿曲库铵持续输注对机械通气SD 大鼠膈肌功能
的影响 |
| Continuous Infusions of Rocuronium and Cisatracurium Exert DifferentEffects on SD Rat Diaphragm Function during Mechanical Ventilation |
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| DOI： |
| 中文关键词: 罗库溴铵 机械通气 膈肌 危重症肌病 |
| 英文关键词: Rocuronium Mechanical ventilation Diaphragm Critical illness myopathy |
| 基金项目:国家自然科学基金（30972859） |
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| 中文摘要: |
| 目的：比较罗库溴铵或顺式阿曲库铵24 h 持续输注对机械通气SD 大鼠膈肌功能的影响。方法：雄性SD 大鼠随机分为四
组：一组作为对照组，另外三组用来进行24 h 的机械通气。其中一组为罗库溴铵组持续输注罗库溴铵，一组顺式阿曲库铵和一组
生理盐水。结果：24 h 机械通气后，与生理盐水组相比，罗库溴铵组的膈肌最大强直张力下降29%，膈肌MuRF-1 的mRNA 水平增
加30 %，calpain 活性增加约57 %，而等效剂量的顺式阿曲库铵组则没有明显改变。结论：与顺式阿曲库铵相比，罗库溴铵可引起
Calpain 活性的增强和泛素- 蛋白酶体系统的激活，对膈肌功能的损害和蛋白水解活性的增强作用更明显。 |
| 英文摘要: |
| Objective: The aim of our study was to compare the effects of 24 h infusion of rocuronium or cisatracurium on the
diaphragm in mechanically ventilated SD rats. Methods: Male SD rats were randomly divided into four groups: a control group(CON)
and three groups submitted to controlled mechanical ventilation for 24h. Among them, MVR group received a continuous infusion of
rocuronium, while MVC with cisatracurium and MVS with 0.9% NaCl. Results: After 24h mechanical ventilation, in vitro diaphragm
tetanic force was decreased after rocuronium (-29 % vs. saline), while the force was more preserved after equivalent dose infusion of
cisatracurium. Diaphragmatic MuRF-1 mRNA was increased after rocuronium (+30 %vs. saline), while unchanged in cisatracurium
group. Calpain activity was increased after rocuronium (+57 % vs. saline) and unchanged in the cisatracurium groups. Conclusion:
Cisatracurium infusion during controlled mechanical ventilation exerted less detrimental effects on diaphragm function and proteolytic
activity than infusion of rocuronium. These data suggest that increased calpain activity and increased activation of the ubiquitin
proteasome system play a role in the different effects of these agents. |
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