| 陈岳涛1 曹蔚1 王四旺1△ 叶青雅2.丹皮酚抗肿瘤作用及其机制研究[J].,2012,12(21):4163-4165 |
| 丹皮酚抗肿瘤作用及其机制研究 |
| The Progress in the Antitumor Effect and Mechanism of Paeonol |
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| DOI： |
| 中文关键词: 丹皮酚 抗肿瘤 作用机制 凋亡 |
| 英文关键词: Paeonol Antitumor Mechanism Apoptosis |
| 基金项目:陕西省"13115" 科技创新工程资助项目（2010ZDGC-19） |
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| 中文摘要: |
| 丹皮酚主要通过杀伤肿瘤细胞、诱导凋亡，影响肿瘤血管生成，促进IL-2 及TNF-α 生成，下调COX-2 表达发挥抗肿瘤作用；
但我们研究证实丹皮酚对体外神经胶质瘤U251 细胞及肝癌HepG2 细胞无明显抑制作用。丹皮酚作为抗肿瘤有效中药分子开发
新药尚需深入的体内外实验研究与探讨。 |
| 英文摘要: |
| To summarize the progress in the antitumor effect and mechanism of Paeonol. Sum up the progress of studies on antitumor
effect of Paeonol and its molecular mechanisms after a wide range of data collection. Paeonol can exert its anti-tumor effect by
killing tumor cells, inducing apoptosis of tumour cell, inhibiting tumor angiogenesis, stimulating secretion of IL-2 and TNF-α and
down-regulating expression of COX-2. Our research suggests that Paeonol has no significant effect on inhibiting proliferation of U251
cells and HepG2 cells. It needs deep discussion and study to develop Paeonol into an new anti-tumor drug as an effective Molecule of
Chinese hebral drug. |
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