| 黄闪王瑾李登举曹阳周晓曦李钦璐姜利军周剑峰徐丹梅△.凋亡抑制蛋白XIAP 在急性髓系白血病和淋巴瘤骨髓组织中
的表达及意义[J].,2012,12(20):3857-3859 |
| 凋亡抑制蛋白XIAP 在急性髓系白血病和淋巴瘤骨髓组织中
的表达及意义 |
| Expression and Clinical Significance of XIAP Protein in the BoneMarrow Tissue of Acute Myeloid Leukemia and Lymphoma |
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| DOI： |
| 中文关键词: 白血病 淋巴瘤 XIAP |
| 英文关键词: Acute myeloid leukemia Lymphoma XIAP |
| 基金项目: |
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| 中文摘要: |
| 目的：研究凋亡抑制蛋白（XIAP）在白血病及淋巴瘤骨髓活检组织中的表达及意义。方法：采用免疫组织化学法检测10 例急
性髓系白血病，13 例淋巴瘤，9 例非恶性血液病患者骨髓活检组织中XIAP 的表达水平。结果：XIAP 蛋白在急性髓系白血病、淋巴
瘤骨髓活检组织中的阳性表达积分均高于非恶性血液病，差异均有统计学意义（P<0.05）。结论：XIAP 的表达水平与白血病及淋巴
瘤的发生发展有一定关联，可能与其抑制肿瘤细胞的凋亡有关。 |
| 英文摘要: |
| Objective: To investigate the expression and clinical significance of the X-linked inhibitor of apoptosis protein (XIAP )
in bone marrow biopsy tissue of acute myeloid leukemia and lymphoma. Methods: The expression of XIAP was detected by immunohistochemical
assay in the bone marrow biopsy tissue from 10 cases of acute myeloid leukemia, 13 lymphoma and 9 patients without hematological
malignancy. Results: The level of XIAP in the bone marrow tissue from acute myeloid leukemia and lymphoma was higher than
those from control cases without hematological malignancy (P＜0.05）. Conclusion:The increased expression of XIAP protein may contribute
to the progression of acute myeloid leukemia and lymphoma, which may be relevant to its role as inhibitor of apoptosis. |
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