| 谢小妹陈龙△ 黄江琼梁霞张晓静.术前血清CEA 水平与非小细胞肺癌预后关系的Meta 分析*[J].,2012,12(19):3689-3692 |
| 术前血清CEA 水平与非小细胞肺癌预后关系的Meta 分析* |
| Prognostic Significance of Preoperative Serum Carcinoembryonic Antigen inNon-Small Cell Lung Cancer:A Meta-Analysis |
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| DOI： |
| 中文关键词: 非小细胞肺癌 CEA 预后 Meta 分析 |
| 英文关键词: Non-Small Cell Lung Cancer Carcinoembryonic Antigen Prognosis Meta-Analysis |
| 基金项目:广西自然科学基金项目（2011jjA40272） |
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| 中文摘要: |
| 目的：采用Meta 分析的方法评估术前血清CEA(carcinoembryonic antigen)高水平与非小细胞肺癌(NSCLC)预后之间的关系。
方法：从PubMed、EMBASE 数据库中查找血清CEA 水平与NSCLC 预后关系的相关研究，收集每篇文献的相对危险比(hazard
ratio, HR)以及95%可信区间(95%C1)，应用Meta 分析Dersimonian-Laird 模型对文献进行定量综合分析。结果：共入选13 篇文献，
累计研究CEA 与NSCLC 预后关系的病例3505 例。对入选13 篇文献进行一致性检验，文献具有异质性(Q=2201.96，P=0.000)，合
并相对危险比HR 为2.33(95%可信区间：2.03-2.68，P=0.000)。结论：术前血清CEA 高浓度水平可能是NSCLC 的不良预后因素。 |
| 英文摘要: |
| Objective: To evaluate the relationship between elevated preoperative serum CEA and the prognosis of non-small cell
lung cancer by a meta-analysis. Methods: Searched Articles on the correlation of elevated concentration of preoperative serum CEA
expression with the prognosis of non-small cell lung cancer from Medline and Embase,extracted the HR (hazard ratio)and 95%CI
(confidence interval)in every article.Analyzed the results of 13 studies by Dersimonian-Laird method. Results: 3505 patients of the
relation between the level of CEA and NSCLC prognosis researched from 13 studies were included. The analysis for homogeneity(Q
statistics test)showed that all eligible studies were with heterogeneity (Q=2201.96,P=0.000). The combined HR was 2.33 and 95%CI was
2.03-2.68, P=0.000. Conclusion : High concentrations of Preoperative CEA may be the poor prognosis factor of non-small cell lung
cancer. |
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