| 彭学勤甘润良△.肿瘤病毒的发现历程及在肿瘤发生机制中的研究意义[J].,2012,12(18):3596-3600 |
| 肿瘤病毒的发现历程及在肿瘤发生机制中的研究意义 |
| Finding History of Tumor Virus and Significance of Tumorigenesis Research |
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| DOI： |
| 中文关键词: 肿瘤病毒 癌症 致瘤机制 |
| 英文关键词: Tumor virus Cancer Tumorigenic mechanism |
| 基金项目: |
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| 摘要点击次数: 885 |
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| 中文摘要: |
| 1911 年Peyton Rous 发现禽肉瘤病毒，从而建立了肿瘤病毒学这一学科领域。20 世纪30 年代，Richard 发现哺乳动物肿瘤
病毒，60 年代发现第一个人类肿瘤病毒--EB 病毒，随后相继鉴定出乙型肝炎病毒（HBV）和乳头状瘤病毒（HPV）。肿瘤病毒的深
入研究带动了癌基因概念的确立和抑癌基因功能的发现，促进癌症疫苗的研究，后者可以抑制病毒的传染性并降低肿瘤的发病
率。20 世纪80-90 年代发现了人T 细胞白血病Ⅰ型病毒（HTLV-1），丙型肝炎病毒（HVC）及卡波西肉瘤病毒（KSHV）。目前已知6
种病毒（EBV、HBV、HPV、HTLV-1、HCV、KSHV）引起世界范围10%-15%的癌症，因此，病毒不仅是许多人类癌症的病原体，还可
以作为揭示人类恶性肿瘤发病机制的研究工具。 |
| 英文摘要: |
| Peyton Rous established the scientific field of tumor virology in 1911 by discovering Rous sarcoma virus. In 1930s
Richard identified mammalian tumor viruses, and the first human tumor virus-EBV was discovered in 1960s, and hepatitis B virus and
the papillomaviruses then followed. The thorough research of tumor virus spurred the concept of oncogenes and the identification and
function of tumor suppressor genes, and promoted the cancer vaccine research, which can inhibit virus infection and decrease tumor incidence.
In the 1980s and 1990s, additional human tumor viruses--human T-cell leukemia virus type 1, hepatitis C virus, and Kaposi's sarcoma
herpesvirus were identified. Current estimates suggest that six kinds of viruses （EBV, HBV, HPV, HTLV-1, HCV, KSHV）are involved
in 15% to 20% of human cancers worldwide. Thus, viruses not only have been shown to represent etiologic agents for many human cancers
but also have served as tools to reveal mechanisms that are involved in human malignancies. |
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