| 杨洪1 许敏2 屈园园1 胡凤侠1 马红艳1.类风湿性关节炎与系统性红斑狼疮重叠综合征一例报告及文献复习[J].,2012,12(18):3519-3521 |
| 类风湿性关节炎与系统性红斑狼疮重叠综合征一例报告及文献复习 |
| Clinical Manifestations of Coexistent Rheumatoid Arthritis and SystemicLupus Erythematosus (Rhupus syndrome) |
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| DOI： |
| 中文关键词: 类风湿关节炎 红斑狼疮 Rhupus 综合征 |
| 英文关键词: Rheumatoid arthritis Lupus erythematosus Rhupus syndrome |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨类风湿关节炎（RA）与系统性红斑狼疮（SLE）重叠综合征（Rhupus 综合征）的临床表现及治疗方法，以期提高对本
病的认识。方法：对1 例类风湿关节炎（RA）与系统性红斑狼疮（SLE）重叠的Rhupus 综合征患者的病例资料进行分析。结果：本例
患者为中年女性，以RA 为首发表现，8 年后出现SLE 特征性表现。就诊时关节症状较严重, 出现多关节变形。本例患者肾脏损害
重，糖皮质激素联合甲氨喋呤治疗有效。结论：Rhupus 综合征在临床上罕见，加强特异性抗体检查，可减少误诊漏诊，早期正确诊
断，积极治疗，对于改善患者预后具有重要意义。 |
| 英文摘要: |
| Objective: To investigate the clinical manifestations and therapeutic approach of coexistent rheumatoid arthritis (RA)
and systemic lupus erythematosus ( SLE) (Rhupus syndrome). Methods: Clinical data from a patient with Rhupus syndrome were analyzed
combined with literature review. Results: The patient was a middle-aged female, who had presented with features of RA and developed
features of SLE 8 years later. The patient had severe renal dysfunction and showed part remission with glucocorticosteroids and
methotrexate therapy. Conclusions: Rhupus syndrome is a rare condition sharing features of RA and SLE. Early diagnosis and aggressive
treatment might improve the prognosis. |
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