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目的：研究内镜下注射1%乙氧硬化醇和注射1:10 0000 肾上腺素治疗食管贲门粘膜撕裂综合症的疗效及安全性。方法：按照随机抽样的原则，从行急诊胃镜检查确诊为食管贲门粘膜撕裂综合症并行内镜下止血治疗的患者中，随机抽取58 例患者，按随机数字表法分为治疗组29 例和对照组29 例，治疗组采用内镜下注射1%乙氧硬化醇，对照组采用内镜下注射1:10 0000 肾上腺素，观察两组患者首次止血成功率，早期、近期、远期再出血率，并发症发生率等。结果：治疗组首次止血成功率96.55%（28/29），对照组首次止血成功率93.10%（27/29），两组差异无统计学意义（P>0.05），治疗组早期再出血率7.41%（2/28），显著低于对照组 29.63%（8/27）（P<0.05），治疗组近期及远期再出血率为3.57%（1/28），对照组近期及远期再出血率3.70%（1/27），两组差异无统计学意义（P>0.05），两组均无栓塞、穿孔、死亡等并发症出现。结论：内镜下注射乙氧硬化醇治疗食管贲门粘膜撕裂综合症优于注射肾上腺素。

英文摘要:

Objective: To investigate the effect of endoscopic sclerosing agent injection on treatment of Mallory-Weiss syndrome. Methods: The 58 patients who diagnosed as Mallory-Weiss syndrome by immediate endoscopy and received endoscopic therapy were randomly divided into 2 groups: endoscopic aethoxysklerol injection (n=29) and endoscopic 1:100000 epinephrine injection (n=29). The hemostasis rate, re-bleeding rate and complication rate were compared. Results: Initial hemostasis in therapy group was 96.55%. Initial hemostasis in control group was 93.10％. There was no significant difference (P>0.05). The rate of early re-bleeding in therapy group was 7.41%, which was significantly lower than that of 29.63% in control group. The rate of re-bleeding in the near future and long-term in therapy group was both 3.57%, while which in control group was both 3.70%, and there was no significant differences between the 2 groups. There was no patient complicated of ectopic embolism, perforation and death in the two groups. Conclusions: Endoscopic aethoxysklerol injection is better than endoscopic 1:10 0000 epinephrine injection in treating Mallory-Weiss syndrome.

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