| 张歆薇刘海强徐胜龙周艳郭国祯△ 王晋△ 丁桂荣△.次声作用对大鼠血浆SOD、MDA、NO 水平的影响*[J].,2012,12(18):3416-3419 |
| 次声作用对大鼠血浆SOD、MDA、NO 水平的影响* |
| Effects of Infrasound on the Levels of SOD, MDA and NO in Rat Plasma* |
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| DOI： |
| 中文关键词: 次声 大鼠 超氧化物歧化酶 丙二醛 一氧化氮 |
| 英文关键词: Infrasound Rats Nitric oxide Malondialdehyde Superoxide dismutase |
| 基金项目:国家973 项目（2011CB503704，2011CB503705），国家自然科学基金项目（81072272，60871068） |
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| 中文摘要: |
| 目的：通过观察16 Hz/130 dB 次声作用大鼠不同时间其血浆超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）水平的
变化，揭示次声作用对大鼠氧化应激损伤的特点。方法：80 只SD 大鼠随机分为次声作用1、7、14、21 和28 d 组及对应的假暴露
组，每组8 只大鼠。次声暴露组每日定时在次声舱内接受16 Hz/130 dB 次声作用2h，连续1、7、14、21 和28 d，假暴露组除不施加
次声作用外，其在次声舱中放置的时间、次数、采样时间点均和次声暴露组相同。次声暴露后即刻测定大鼠血浆SOD、MDA、NO
水平，测得的结果与假暴露组进行比较。结果：与假暴露组相比，大鼠血浆SOD 活力在次声作用后显著降低（P<0.05），且随次声作
用时间延长，SOD 活力逐渐降低；大鼠血浆MDA 含量在次声作用后显著升高（P<0.05），且随次声作用时间延长，MDA 含量逐渐
升高；大鼠血浆NO 含量在次声作用7、14 d 时显著降低（P<0.05），1、21 和28 d 时无统计学差异（P>0.05）。结论：次声作用可引起
大鼠氧化应激损伤，损伤的程度与次声暴露时间有关。 |
| 英文摘要: |
| Objective: To observe the effects of infrasound on the levels of SOD, MDA and NO in rat plasma. Methods: 80 SD rats
were randomly divided into five sham groups and five infrasound exposed groups (n=8). The rats in exposed groups were exposed under
infrasound of frequency at 16 Hz, sound pressure level at 130 dB for 1, 7, 14, 21 and 28 d, 2 h per day, the rats in sham groups were treated
the same except infrasound exposure. The levels of SOD, MDA and NO in plasma were measured immediately after final exposure.
Results: Comparing to sham groups, the activety of SOD in rat plasma decreased significantly after infrasound exposure for 1, 7, 14, 21
and 28 d (P<0.05), the content of MDA in rat plasma increased significantly after infrasound exposure for 1, 7, 14，21 and 28 d (P<0.05),
the content of NO in plasma decreased significantly at 7 d (P<0.05)and 14 d (P<0.05), at 0, 21 and 28 d normally (P>0.05). Conclusion:
Infrasound could induce oxidative stress in a time-dependent manner in rats. |
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