| 潘运迎邓征浩周建华△.FGF-2 在细胞凋亡中的作用机制[J].,2012,12(17):3394-3397 |
| FGF-2 在细胞凋亡中的作用机制 |
| The Role of FGF-2 in the Mechanism of Apoptosis |
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| DOI： |
| 中文关键词: 成纤维细胞生长因子2 肿瘤 细胞凋亡 信号传导 |
| 英文关键词: Fibroblast growth factor 2 Tumor Apoptosis Signal transduction |
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| 中文摘要: |
| 成纤维细胞生长因子2（fibroblast growth factor 2，FGF-2）具有多种细胞生物学功能。FGF-2 在肿瘤组织中呈高水平表达状
态，且可抑制多种化疗药物的促凋亡作用，从而曾为肿瘤细胞存活的重要刺激因素。但也有研究表明FGF-2 可诱导部分细胞的分
化和凋亡。鉴于FGF-2 在肿瘤的发生发展中发挥的重要作用，FGF-2 与细胞凋亡的关系及其相应的调节机制成为有待于深入研
究和迫切需要解决的问题。本文主要阐述在细胞凋亡通路中，FGF-2 关键分子的作用机制及其最新研究进展。 |
| 英文摘要: |
| The last growth factor 2 (FGF-2) has a variety of cell biological functions. In a number of tumor cells, the expression
of FGF-2 is in high level, and FGF-2 can inhibit many pro-apoptotic effects of chemotherapy drugs, so that it is considered as a powerful
stimulus of tumor cell survival. However, in some cell lines, FGF-2 can induce cell differentiation and apoptosis. According to the
important role of FGF-2 in tumor development, the relationship between FGF-2 and cell apoptosis and its corresponding mechanism is to
be in-depth study and urgent need to be solved. This review focuses on the role of key intermediary molecular of FGF-2 in apoptotic
pathway and its recent progress. |
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