文章摘要
陈双1 甘冠华2 楚凤婷3 冯齐平3.颊粘膜癌与舌癌差异基因表达的对比分析[J].,2012,12(16):3144-3146
颊粘膜癌与舌癌差异基因表达的对比分析
Differences of Gene Expression Profile between Buccal MucosaCancer and Tongue Cancer
  
DOI:
中文关键词: 颊粘膜癌  舌癌  基因表达
英文关键词: Buccal mucosa cancer  Tongue cancer  Gene expression
基金项目:2010 年上海基础研究计划(10ZR1432199)
作者单位
陈双1 甘冠华2 楚凤婷3 冯齐平3 上海市田林街道社区卫生服务中心口腔科 
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中文摘要:
      目的:研究颊粘膜癌(Buccal Mucosa Cancer, BMC)与舌癌(Tongue Cancer, TC)的基因差异表达,探讨BMC 与TC 发生发展 的基因学基础。方法:应用cDNA 芯片技术对5 例BMC 和5 例TC 组织mRNA 检测,通过芯片杂交、生物信息学处理,找出两者 间差异表达基因。结果:BioStarH-40 芯片发现差异表达基因503 条,差异表达基因占12.9% ,其中表达增强274 条(显著增强69 条),表达降低229 条(显著降低54 条)。结论:MBC 与TC 基因表达比较,差异有统计学意义,这些差异可能在两类肿瘤不同的生 物学行为中起重要作用。
英文摘要:
      Objective: To determine the difference in the gene expression between human buccal mucosa cancer (BMC) and tongue cancer (TC). Methods: cDNA chip was used to detect the mRNA of cancer tissue from 5 BMCs and 5 TCs. After profile bloted and handled by bioinformation, the gene expression of these two kinds of lesions was examined. Results: Using the BioStarH-40 profile, 503 different expression of genes were found. The rate of different genes was 12.9%, of which the exprssion of 274 genes increased(69 genes significantly increased) and 229 genes decreased (54 genes significantly decreased ) in BMC tissue than that in TC. Conclusions: The gene expression ofBMCandTCwas different,whichmaycontribute to the different biological behavior ofthese two kinds oflesions.
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