| Objective: To study the relationship between the dissolution effect of bile duct stones and the different molar ratio of
sodium cholate and disodium edetate, drug concentrations, and the time in the bile. Methods：To design the three dissolution experiments
that the total drug concentration was 0.1% in the bile within one month, and the molar ratio of sodium cholate and disodium edetate was
0:1,8:1,4:1,2:1,1:1 1:2,1:4,1:8 and 1:0; that the molar ratio was 1:1, and drug concentrations in the bile were 0, 0.1%, 0.2%, 0.4%, 0.8%,
1.6% and 3.2% in within one month; that that the molar ratio was 1:1, drug concentration was 0.1%, and the time were 0,1,2,4,8,16,32
and 64d.To assess the quality loss of stones in the three experiments was equal (P <0.05 statistical significance). Results：Tt the total drug
concentration of 0.1% in one month, disodium edetate dissoluted more stones than sodium cholate, and complex drugs dissoluted more
stones than a single agent, and the closer the molar ratio of 1:1, the stronger dissolution ability, the strongest was 1:1. At complex drug of
1:1 in one month, the higher the drug concentration, the stronger dissolution ability. In the conditions of sufficient dissolution drugs, the
total drug concentration of 0.1%, and the molar ratio of 1:1, the longer, the more the quality loss of stones (P<0.05, significant statistical
significance). Conclusion：When the sodium cholate and sodiumcholate was 1:1,the complex drugs have the strongest dissolution effect;
in the condition of sufficient dissolution drugs, the higher the drug concentration, the longer, the more the quality loss of stones. |
