| 王健 邹仲敏 赵吉清.MiR-203 及其调控机制的研究进展[J].,2012,12(14):2743-2747 |
| MiR-203 及其调控机制的研究进展 |
| The Research Progress of MiR-203 and its Regulation Mechanisms |
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| DOI： |
| 中文关键词: MiR-203 调控 皮肤 |
| 英文关键词: MiR-203 Regulation Skin |
| 基金项目:国家自然科学基金面上项目（31171118） |
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| 中文摘要: |
| MicroRNA(miRNA)是一种长18-25 个碱基的单链非编码RNA，其广泛参与机体众多病理、生理过程。MiR-203 是一种上皮
组织特异性表达的miRNA。研究发现miR-203 在皮肤发育、皮肤相关疾病、上皮组织肿瘤等病理、生理过程中发挥重要调控作用。
一些疾病的研究还发现了miR-203 与表观遗传学机制的相互作用, 而miR-203 调控机制的研究集中在P63、SOCS-3 及相关的信
号通路等方面。 |
| 英文摘要: |
| MicroRNAs (miRNA) are 18-25-nucleotide, single-stranded, non-coding RNAs that participate in many pathological
and physiological processes of the body. MiR-203 is a miRNA specially expressed in epithelial tissue. Researches show that miR-203
plays an important role in skin development, skin-related diseases, epithelial tumors and other pathological and physiological processes.
The interaction between miR-203 and epigenetic mechanisms is also discovered in the researches on some diseases, while the researches
on the regulation mechanisms of miR-203 focus on P63, SOCS-3 and related signal pathways. |
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