| 邱晋任小宝△ 陈翔宇李科陈小雄.奥曲肽治疗急性粘连性肠梗阻疗效观察[J].,2012,12(12):2319-2321 |
| 奥曲肽治疗急性粘连性肠梗阻疗效观察 |
| Efficacy of Octreotide for the Treatment of Acute AdhesiveIntestinal Obstruction |
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| DOI： |
| 中文关键词: 粘连性肠梗阻 奥曲肽 生长抑素 |
| 英文关键词: Adhesive intestinal obstruction Octreotide Somatostatin |
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| 中文摘要: |
| 目的：探讨生长抑素对腹部手术后急性粘连性肠梗阻的治疗作用。方法：70 例急性粘连性肠梗阻患者随机分为观察组与对
照组各35 例。对照组予胃肠减压、灌肠、补液及抗感染治疗等常规治疗；观察组在此基础上加用奥曲肽(生长抑素类似物)0.1 mg
皮下注射，每8h 一次，治疗72 h。观察两组患者腹痛评分、腹痛缓解时间、胃肠减压量、肛门恢复排气时间、立卧位腹部平片、临床
缓解情况。结果：观察组34 例(97.1%)临床缓解，明显高于对照组的28 例(80.0%) (P<0.05)。与对照组相比，观察组在治疗第1、2
天后腹痛评分明显下降(均为P<0.01)，腹痛缓解时间显著缩短(P<0.01)，治疗第1、2、3 天的胃肠减压量均显著减少(均为P<0.01)，
恢复排气时间也明显缩短(P<0.01)。结论：急性粘连性肠梗阻在常规治疗基础上加用生长抑素，可明显改善临床症状，提高疗效。 |
| 英文摘要: |
| Objective: To investigate the efficacy of octreotide for the treatment of acute adhesive intestinal obstruction.Methods:
70 patients with acute adhesive intestinal obstruction were randomly divided into observation group and control group with each of 35
cases. Control group were treated with decompression, enemas, rehydration and anti-infection drugs and such as conventional treatment.
On this basis, observation group was added with octreotide (somatostatin analogue)0.1mg subcutaneously, once every 8h, treatment for
72 h. Abdominal pain score, pain relief time, the amount of decompression, anal exhaust time to restore, establish supine abdominal plain
film and clinical remission were observed. Results: 34 patients (97.1% ) of the observation group got clinical remission, which was
significantly higher than 28 cases (80.0%) of the control group (P<0.05). Compared with the control group, the abdominal pain score of
the observation group was significantly decreased at 1 and 2 days after treatment (P<0.01), and pain relief time was significantly shorter
(P<0.01), gastrointestinal decompression volume decreased significantly at 2 and 3 days after treatment (P<0.01), recovery time was
significantly shorter (P<0.01). Conclusion: Based on the conventional treatment, somatostatin can significantly improve the clinical
symptoms and efficacy for the treatment of acute adhesive intestinal obstruction. |
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