| 蔡云鹏马柳青张文君王兆敏张袁魁朱云婷袁伟恩△.苄丝肼微球的体外释放行为[J].,2012,12(11):2158-2159 |
| 苄丝肼微球的体外释放行为 |
| Release of Benserazide-loaded Microspheres in Vitro |
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| DOI： |
| 中文关键词: 苄丝肼 微球 缓释 包封率 |
| 英文关键词: Benserazide Microspheres Sustained release Encapsulation efficiency |
| 基金项目:国家重大专项－" 重大新药创制" 制剂平台（2009ZX09310-007）；国家自然科学基金（81171203）；
上海科委纳米专项（1052nm03900）；上海交通大学大学生创新项目（IPP2090） |
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| 中文摘要: |
| 采用S/O/W 和W/O/W 法，和不同的苄丝肼载药量制作缓释微球，用HPLC 考察其释放曲线、突释情况和包封率，实验表明
S/O/W 法制作的苄丝肼微球缓释效果更好，达到了6d，包封率能达到70%以上，突释情况可以接受，苄丝肼载药量低的微球能达
到更高的包封率。 |
| 英文摘要: |
| To prepare benserazide-loaded sustained release microsphere using W/O/W and S/O/W method, and with different
amount of drug loading. The release was detected by HPLC, and analyzed the drug release, initial burst and the encapsulation efficiency.
The results suggest that the microspheres made by S/O/W method work better in sustained release, which reaches 6 days, the encapsulation
efficiency can be more than 70%, the initial burst is acceptable, and the lower the drug loading is, the higher the encapsulation efficiency
can be. |
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