| 汪菲崔亮王晓雄△ 高江平高春记曾强.原发性肾上腺非霍奇金淋巴瘤（附9 例报告）[J].,2012,12(11):2074-2076 |
| 原发性肾上腺非霍奇金淋巴瘤（附9 例报告） |
| Primary Adrenal Non-Hodgkin's Lymphoma: Report of 9 Cases |
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| DOI： |
| 中文关键词: 肾上腺 淋巴瘤 非霍奇金 诊断 预后 |
| 英文关键词: Adrenal gland Lymphoma Non-Hodgkin Diagnosis Prognosis |
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| 中文摘要: |
| 目的：探讨原发性肾上腺淋巴瘤（Primary Adrenal Lymphoma, PAL）的临床特点、提高对PAL 的认识。方法：回顾分析解放军
总医院1995 年12 月至2007 年6 月收治的9 例PAL 的临床表现、实验室检查、影像学特点、组织病理类型以及治疗方法等临床
资料，并结合国内外文献进行分析。结果：9 例患者中，1 例因常规体检发现，8 例因腹痛、腹胀或腰痛就诊发现；其中单侧3 例，双
侧6 例，实验室检查无明显异常，影像学检查仅发现肾脏肿瘤，但术后病理组织学诊断为非霍奇金淋巴瘤(non-Hodgkin's lymphoma,
NHL)，其中8 例弥漫大B 细胞淋巴瘤，1 例T 细胞淋巴瘤；7 例患者术后均接受了CHOP 或RCHOP 方案化疗为主的综合
治疗，2 例常规治疗；随访至2010 年2 月，1 例弥漫性大B 细胞淋巴瘤患者存活4 年，1 例在术后3 年2 个月死亡，余7 均在2 年
内死亡。结论：PAL 是一种罕见的、恶性程度较高的肿瘤，临床表现和影像学检查缺乏特异性，组织病理学及免疫组织化学是明确
诊断的好方法。术前确诊肾上腺原发性非霍奇金淋巴瘤可避免手术，联合化疗应为治疗首选。 |
| 英文摘要: |
| Objective:To investigate the clinical characteristics of primary adrenal non-Hodgkin's lymphoma (PAL), so as to improve
comprehension of that unusual lesions. Methods: Nine cases of patients with a confirmed diagnosis of PAL were retrospectively reviewed.
The clinical presentation, laboratory examination, imaging characteristics, histopathology types and treatment were analyzed. Results: 1
casewas occasionally detected by health examination and 8 patients complained of stomachache, abdominal distension or lumbago. 3 patients
were unilateral lymphoma, and other patients were bilateral. There was non-apparent abnormality in the check of laboratory. The adrenal
tumors were found by imaging examination, but the diagnosis of non-Hodgkin's lymphoma (NHL) was confirmed by histopathological
examination. 8 cases were diffuse B-cell origin lymphoma and 1 case was T-cell origin lymphoma. They all received CHOP or RCHOP
chemotherapy. Follow up over in February, 2010, 1 patient has been alive for 4 years and 1 patient died postoperative 3 years and 2
months, other 7 cases died within 2 years. Conclusions: PAL is a rare malignancy. The presenting symptoms and imaging modalities of
PAL were nonspecific and misdiagnosis rate was high. The definitive diagnosis of PAL depended on histopathology and immunohistochemistry
of adrenal tissue. Surgical operative could be avoided if the diagnosis was made preoperative. The primary management in the
treatment of PAL was combination chemotherapy. |
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