| 王明辉1 万荣1,2△ 程细祥3,4 王兴鹏1 刘占举1 郑萍2.IL-23 受体基因多态性和克罗恩病的相关性研究[J].,2012,12(11):2014-2016 |
| IL-23 受体基因多态性和克罗恩病的相关性研究 |
| Relativity Research on the Interleukin(IL)-23 Receptor Gene Polymorphismand Crohn's Disease |
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| DOI： |
| 中文关键词: 克罗恩病 白细胞介素23 受体 多态性 限制性片段长度 基因 |
| 英文关键词: IL-23R Polymorphism Restriction fragment length Grhon's disease Genes |
| 基金项目:上海市科委基金(08411962900; 08411962900) |
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| 中文摘要: |
| 目的：探讨白介素23 受体（IL-23R）基因rs11465779 位点多态性与克罗恩病（Crohn's Disease，CD）的关系。方法：从98 例上
海本地汉族CD 患者和90 例正常对照者外周血标本中提取基因IBD 组DNA，用聚合酶链式反应- 限制性片段长度多态
(PCR-RFLP) 技术检测IL-23R 基因rs11465779 位点变异情况，分析其基因表型、基因频率与IBD 的关系。结果：IL-23R 基因
rs11465779 位点基因型和等位基因频率在CD 组和对照组中分布差异无显著性(P>0.05)，且该位点多态性和CD 发病年龄及性别
均无相关。结论：IL-23R 基因rs11465779 位点多态性变异，可能不是中国南方汉族人群CD 发病的危险因素。 |
| 英文摘要: |
| Objective: To explore the association between the polymorphlsm of IL-23R gene and Crhon's disease (CD). Methods:
Total 98 CD patients, and 90 healthy individuals were studied. The alleles and gene type of rs11465779 were analyzed by restriction fragment
length polymorphism (PCR-RFLP). Results: The frequency of alleles and gene type were similar between CD and normal group
(P<0.05). Further analysis also did not display any relationship between the polymorphism and the onsetage or sex of CD(P>0.05).
Conclusion: The rs11465779 of IL-23R gene is not associated with susceptibility to Crhon's disease in Han population of South China． |
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