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目的：本研究旨在观察饮食中添加葛根素对肥胖型高血压大鼠的心血管代谢指标的影响，尤其关注其对于血压和血管功能的效应。方法：①自发性高血压大鼠24 只，分正常饮食对照组（8 只）、高脂饮食组（8 只）、高脂饮食+ 葛根素组（8 只），大鼠先进行1 周的适应性喂养，1 周后进行干预，干预时间为14 周；②每周测1 次体重、鼠尾血压；③ 实验结束时空腹取血浆测血脂、血糖值，取胸主动脉观察主动脉的内皮依赖性及非内皮依赖性舒张功能。结果：①葛根素可防止高脂饮食导致的自发性高血压大鼠体重的增加及血压、血糖的升高，与高脂饮食组比较，P<0.05 或P<0.01。②长期葛根素喂养可有效防止高脂饮食导致的高血压大鼠的血脂水平升高；③长期的葛根素喂养可显著改善肥胖型高血压大鼠的血管舒张功能及降低血压。结论：葛根素可有效改善肥胖型高血压大鼠的相关代谢指标，并可明显降低血压及改善血管功能，提示葛根素对肥胖型高血压有较好的防治作用，值得进一步深入研究。

英文摘要:

Objective: To investigate the effects of dietary contain puerarin on the cardiometabolic indexes on obesity-hypertension rats, especially the blood pressure and the vascular fuction. Methods: Eight weeks old Spontaneously Hypertensive Rats were divided into three groups-the control group, give the normal chow, high fat diet group, give the high fat diet, the high fat diet and the puerarin group, give the high fat diet contain 0.1% puerarin, each group has eight rats, and the intervention time is 14 weeks. The tail blood pressure and the body weight were detected every week. And at the end of the study, the rats were fasting for 12hrs and the blood sample was took to detected the fasting blood glucose and lipids levels. Lastly the endothelium-dependent and the endothelium-independent relaxation of the aorta were detected by wire myograph. Results: The high fats diet increased the body weight which lead to obesity, rise the lipids levels, the blood pressure level and fasting blood glucose level in SHR. Dietary puerarin administration decreased the body weight thus prevents obesity compared with that in the control group P<0.01 or P<0.05. More importantly, it can improved the endothelium-dependent relaxation of the aorta artery and lower the blood pressure level, compared to the high fat group, P<0.01 or P<0.05. Conclusion: Dietary puerarin had the cardiometabolic protection. It can improved the vasorelaxation and decreased the blood pressure, indicating that the puerarin had the perspective in treatment of obesity hypertension.

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