| 张丽娜1 冯彩华2 柴薪1 王丛丛1 董海龙1△.伏隔核微注射orexin-A 对大鼠摄食和活动的影响[J].,2012,12(9):1621-1623 |
| 伏隔核微注射orexin-A 对大鼠摄食和活动的影响 |
| The Effect of Orexin-A on Feeding and Locomotor Activity inthe Accumbens |
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| DOI： |
| 中文关键词: 伏隔核 orexin-A 摄食 |
| 英文关键词: Accumbens Orexin-A Feeding |
| 基金项目:国家自然科学基金资助项目（30772075） |
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| 中文摘要: |
| 目的：探讨伏隔核微注射orexin-A 后，大鼠摄食和活动的变化。方法：采用SD 大鼠(250-280g),用脑立体定位仪在伏隔核植
入微量注射管。大鼠随机分组，分别微注射乳酸格林液（Ringer's），orexin-A 100pmol 和500pmol。观察微注射后大鼠0-1h,
1-2h,2-4h 摄食和0-30min,30-60min,60-90min,90-120min 活动性变化。结果：Orexin-A 微注射后，大鼠0-1h, 1-2h 摄食量增加；
30-60min,60-90min,90-120min 的活动性显著增加（P < 0.05 vs 对照组）。结论：伏隔核是orexin-A 刺激大鼠增加摄食量，提高其活
动性的作用点。 |
| 英文摘要: |
| Objective: To investigate the effect of orexin-A on feeding and locomotor activity in the accumbens shell (Accsh).
Methods: SD rats (250-280) were used and implanted a guide cannulae into the accumbens shell (AccSh) by stereotaxic instrument. Then
rats were randomly divided into three group and microinjected Ringer's solution, 100 pmol and 500 pmol orexin-A respectively. The
feeding were recorded in 0-1h,1-2h,2-4h and locomotor activity were recorded in 0-30 min, 30-60min,60-90min,90-120min after micinjection.
Results: Orexin-A augmented feeding in the 0-1 h and 1-2 h and stimulated locomotor activity in the 30-60 min, 60-90 min, and
90-120 min post-infusion (P < 0.05 vs control group). Conclusion: AccSh is a site of orexin A modulation of feeding behavior and locomotor
activity. |
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