| 李志平闫爽△ 姜福丽鞠佳明刘思颖李佳宁周伟彧.血管内皮祖细胞与糖尿病微血管病变研究进展[J].,2012,12(8):1597-1600 |
| 血管内皮祖细胞与糖尿病微血管病变研究进展 |
| Advance in Endothelial Progenitor Cells and DiabeticMicroangiopathy |
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| DOI： |
| 中文关键词: 血管内皮祖细胞 糖尿病微血管病变 糖尿病视网膜病变 糖尿病肾病 糖尿病神经病变 |
| 英文关键词: Endothelial progenitor cells Microvascular disease Diabetic retinopathy Ddiabetic nephropathy Diabetic neuropathy |
| 基金项目:黑龙江省自然科学基金D201020 ；黑龙江省卫生厅课题2010-161 |
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| 中文摘要: |
| 糖尿病微血管病变严重影响了患者生活质量，是患者致死致残主要原因。微血管病变主要表现在视网膜、肾、神经、心肌组
织。微血管病变的机制尚未完全清楚，近年越来越多研究发现血管内皮祖细胞(endothelial progenitor cells, EPCs)是该病发病重要
原因。EPCs 有分化为成熟的内皮细胞并且参与新血管形成和新生的能力。正常情况下内皮损失和EPCs 对内皮的修复作用处于
动态平衡状态，一旦EPCs 受损，内皮损害和修复之间的平衡被打破，内皮层的完整性遭到破坏，必然参与糖尿病血管病变的发生
发展。国内外大量研究证明糖尿病合并大血管病变EPCs 数目功能改变，而糖尿病合并微血管病变EPCs 的怎样变化？本文就
EPCs 与糖尿病微血管病变的关系进行系统综述。 |
| 英文摘要: |
| Diabetic microangiopathy, which is a main cause leading to death and disability, seriously affected the quality of life
in patients. Microvascular disease are mainly expressed in the retina, kidney, nerve, cardiac tissue. Microvascular mechanisms has not
entirely clear and in recent years more and more study show that endothelial progenitor cells (endothelial progenitor cells, EPCs) is the
important reason related to this diseases. EPCs have the ability to differentiate into mature endothelial cells and participate in the
formation and the newborn of the new blood vessels. Normally endothelial damage and the function of EPCs to endothelial repair is in a
state of dynamic balance, and once EPCs is damaged, the balance between endothelial damage and restoration is broken, the integrity of
the endothelial layer is also compromised, which inevitably involved in the occurrence and development of diabetic angiopathy. Numerous
studies at home and abroad prove that diabetes , which is combinated to macroangiopathy , lead to the change about the number and
function of EPCs. however ,how about the changes about the combination of diabetic and microangiopathy EPCs? This article will sysmaticly
describes the relations between EPCs and diabetic microvascular disease. |
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