| 张效林刘腾飞蔡文芝闫承慧梁振洋孙莹冯雪瑶韩雅玲△.中国北方汉族人群Apolipoprotein 基因T-1131C 多态
与急性冠脉综合征的关联研究[J].,2012,12(8):1401-1404 |
| 中国北方汉族人群Apolipoprotein 基因T-1131C 多态
与急性冠脉综合征的关联研究 |
| Association of Apolipoprotein T-1131C with Acute Coronary Syndromein Han Population of North China |
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| DOI： |
| 中文关键词: 冠心病 心肌梗死 基因 单核苷酸多态性 |
| 英文关键词: ApoA5 Acute myocardial infarction Gene Polymorphism |
| 基金项目:军队临床高新技术重大项目(2010GXJS001) , 国家自然科学基金青年科学基金项目（81100135） |
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| 中文摘要: |
| 目的：探讨ApoA5 基因T-1131C 多态性与急性冠脉综合征（acute coronary syndrome，ACS）的相关关系。方法：采用聚合酶
链反应- 限制性片段长度多态性技术结合琼脂糖凝胶电泳和基因测序等方法对675 例ACS 的患者和660 例正常对照组进行检
测，分析ApoA5 基因T-1131C 单核苷酸多态的基因型和等位基因频率的在ACS 组和对照组的分布情况。结果：ApoA5 基因
T-1131C 单核苷酸多态在ACS 组和对照组间的分布频率皆符合Hardy－Weinberg 平衡定律(P＞0.05)，ApoA5 基因T-1131C 单核
苷酸多态三种基因型（TT 型，TC 型和CC 型）在ACS 组分布频率分别为35.4 %，48.1 %和16.4 %，在对照组的分布频率分别为
41.1 %，48.6 % 和10.4 %。ApoA5 基因T-1131C 单核苷酸多态的CC 等位基因在ACS 组和对照组间的分布存在显著性差异(P=0.
002)，C 等位基因是ACS 发病的独立的危险因素1.28 (P=0.002,95% CI=1.09-1.57)。Logistic 回归校正性别、年龄、体重指数、吸烟、
高血压、高脂血症、糖尿病等CAD 易患因素后，ApoA5 基因T-1131C 多态与ACS 的发病仍存在相关关系。结论：在中国北方汉族
人群中ApoA5 基因T-1131C 多态与ACS 的发病相关，ApoA5 基因T-1131C 多态C 等位基因是ACS 发病的独立危险因素。 |
| 英文摘要: |
| Objective: To investigate the relationship between the T-1131C variant of ApoA5 gene and ACS in Han population of
North China. Methods: A case-control study was conducted in 675 patients with ACS and 660 control who had normal coronary
angiograms. Polymorphic genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism,
sequencing analysis. Results: The genotype frequencies in ApoA5 T-1131C polymorphism conformed well to the Hardy-Weinberg equilibrium
in both case and control group. The genotype frequencies of GG, GT and TT of ApoA5 T-1131C polymorphism were 41.1 %, 48.6
% and 10.4 % in the controls, while they were 35.4 %, 48.1 % and 16.4 % in ACS patients respectively. A significantly higher frequency
of CC genotype was observed in ACS patients than that in the controls (P=0.002), The relative risk of ACS in patients carrying C allele
was 1.28 (P=0.002, 95% CI=1.09-1.57). Logistic regression analysis with adjustments for other risk factors revealed that the T-1131C
allele carriers significantly increased risk of ACS compared with the non-carriers. Conclusions: Genetic variations in the ApoA5 gene
promoter may contribute to interindividual variability in risk of ACS. The C allele may play an important role in the occurrence of ACS
and help to predict susceptible individuals. |
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